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Titolo:
INHIBITION OF SORBITOL DEHYDROGENASE - EFFECTS ON VASCULAR AND NEURALDYSFUNCTION IN STREPTOZOCIN-INDUCED DIABETIC RATS
Autore:
TILTON RG; CHANG K; NYENGAARD JR; VANDENENDEN M; IDO Y; WILLIAMSON JR;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,DEPT PATHOL & LAB MED HOUSTON TX 77030 WASHINGTON UNIV,SCH MED,DEPT PATHOL ST LOUIS MO 63110
Titolo Testata:
Diabetes
fascicolo: 2, volume: 44, anno: 1995,
pagine: 234 - 242
SICI:
0012-1797(1995)44:2<234:IOSD-E>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALDOSE REDUCTASE; DIETARY MYOINOSITOL; FILTRATION CHANGES; SCIATIC-NERVE; COMPLICATIONS; MELLITUS; GLUCOSE; ADENOSINE; SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
R.G. Tilton et al., "INHIBITION OF SORBITOL DEHYDROGENASE - EFFECTS ON VASCULAR AND NEURALDYSFUNCTION IN STREPTOZOCIN-INDUCED DIABETIC RATS", Diabetes, 44(2), 1995, pp. 234-242

Abstract

These experiments were undertaken to assess the role of sorbitol dehydrogenase in mediating sorbitol pathway-inked neural and vascular dysfunction in rats with streptozocin-induced diabetes. thyl-4-[N,N-methylsulfamoyl-piperazino]-pyrimidine (S-0773), a putative inhibitor of sorbitol dehydrogenase, was given in the drinking water to control and diabetic rats. After 5 weeks of diabetes, glycosylated hemoglobin levelswere increased twofold and were unaffected by S-0773. Sorbitol levelsin diabetic rats were increased 11- to 14-fold in ocular tissues and sciatic nerve; S-0773 increased sorbitol levels another 4-fold or morein these same tissues but had much smaller effects in other tissues. Diabetes-associated increases in fructose levels and lactate:pyruvate ratios in retina and in sciatic nerve were markedly attenuated by S-0773. S-0773 also attenuated, but did not completely normalize, impairedcaudal nerve conduction and vascular dysfunction in ocular tissues, sciatic nerve, and aorta in diabetic rats. These observations, togetherwith other evidence, suggest that sorbitol pathway-linked vascular dysfunction (in ocular tissues, peripheral nerve, and aorta) and electrophysiological dysfunction (in peripheral nerve) induced by diabetes are more closely linked to increased oxidation of sorbitol to fructose than to putative osmotic effects of elevated sorbitol levels or redox and metabolic imbalances associated with reduction of glucose to sorbitol by aldose reductase.

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Documento generato il 04/12/20 alle ore 19:08:14