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Titolo:
EFFECTS OF ACUTE, SUBACUTE, AND CHRONIC DIABETES ON CARBOHYDRATE AND ENERGY-METABOLISM IN RAT SCIATIC-NERVE - RELATION TO MECHANISMS OF PERIPHERAL NEUROPATHY
Autore:
THURSTON JH; MCDOUGAL DB; HAUHART RE; SCHULZ DW;
Indirizzi:
ST LOUIS CHILDRENS HOSP,DIV PEDIAT NEUROL,1 CHILDRENS PL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT MOLEC BIOL & PHARMACOL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PEDIAT ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT NEUROL & NEUROL SURG ST LOUIS MO 63110
Titolo Testata:
Diabetes
fascicolo: 2, volume: 44, anno: 1995,
pagine: 190 - 195
SICI:
0012-1797(1995)44:2<190:EOASAC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALDOSE REDUCTASE INHIBITOR; DIETARY MYOINOSITOL; CONDUCTION-VELOCITY; SORBITOL PATHWAY; GLYCATION; FRUCTOSE; COMPLICATIONS; PREVENTION; GLUCOSE; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Thurston et al., "EFFECTS OF ACUTE, SUBACUTE, AND CHRONIC DIABETES ON CARBOHYDRATE AND ENERGY-METABOLISM IN RAT SCIATIC-NERVE - RELATION TO MECHANISMS OF PERIPHERAL NEUROPATHY", Diabetes, 44(2), 1995, pp. 190-195

Abstract

To address the problem of the pathogenesis of diabetic neuropathy, rats were made diabetic by alloxan administration, and sciatic nerves were sampled for electrolyte and water content and levels of selected carbohydrates and intermediates in energy metabolism at 3, 6, and 26 weeks. Significant increases were seen in the nerve content of glucose, sorbitol, and fructose. Decreases of myo-inositol were not statistically significant. Glucose-6-phosphate was increased at all times; fructose-1,6-bisphosphate was elevated at 6 and 26 weeks. Nerve ATP and phosphocreatine levels were both increased concomitantly, as was the energycharge. Nerve lactate levels increased only at 26 weeks when plasma lactate levels were also high. Plasma ketone bodies were elevated throughout the 26-week experimental interval, It is postulated that ketone bodies were being used as alternative metabolic fuels in diabetic nerve, thereby causing inhibition of pyruvate oxidation and increased aerobic production of lactate. Increased plasma ketone body levels could also inhibit hepatic lactate uptake. There was no other evidence for hypoxia/ischemia. Lactate:pyruvate ratios did not differ from control values at any time in these ketotic hypoinsulinemic animals. Five major hypotheses have been proposed to explain the pathogenesis of diabetic neuropathy: 1) hypoxia/ischemia, 2) hyperglycemic pseudohypoxia, 3) myo-inositol deficiency, 4) fructose and polyol accumulation and osmoticdisequilibrium, and 5) nonenzymatic glycation of macromolecules by fructose and glucose. The data obtained in this study seem to fit best with hypotheses 4 and perhaps 5.

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Documento generato il 21/09/20 alle ore 12:47:03