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Titolo:
THE ALPHA(6)-INTEGRIN RECEPTOR IN PANCREATIC-CARCINOMA
Autore:
WEINEL RJ; ROSENDAHL A; PINSCHMIDT E; KISKER O; SIMON B; SANTOSO S;
Indirizzi:
UNIV HOSP MARBURG,DEPT SURG,BALDINGERSTR D-35033 MARBURG GERMANY UNIV MARBURG,DEPT SURG W-3550 MARBURG GERMANY UNIV MARBURG,DEPT INTERNAL MED W-3550 MARBURG GERMANY UNIV GIESSEN,INST CLIN IMMUNOL & TRANSFUS MED W-6300 GIESSEN GERMANY
Titolo Testata:
Gastroenterology
fascicolo: 2, volume: 108, anno: 1995,
pagine: 523 - 532
SICI:
0016-5085(1995)108:2<523:TARIP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-SURFACE RECEPTORS; LAMININ RECEPTOR; EXTRACELLULAR-MATRIX; ADHESION MOLECULES; INTEGRIN RECEPTOR; COLLAGEN RECEPTOR; EPITHELIAL-CELLS; BREAST-CANCER; FRAGMENT E8; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Weinel et al., "THE ALPHA(6)-INTEGRIN RECEPTOR IN PANCREATIC-CARCINOMA", Gastroenterology, 108(2), 1995, pp. 523-532

Abstract

Background/Aims: The alpha(6)-containing integrin was sug- gested to be involved in the process of tumor invasion and metastasis. Therefore, the aim of the study was to investigate the expression and function of this adhesion receptor in pancreatic carcinoma. Methods: Integrin expression was investigated in pancreatic tissue and tumor cell lines using immunohistochemistry. Radioimmunoprecipitation was used to determine the complex composition of alpha(6). To analyze the function of the alpha(6)-containing integrin in pancreatic cancer, in vitro adhesion, migration, and invasion experiments were performed. Results: The alpha 6-containing integrin was differentially expressed in normal pancreas and pancreatic carcinoma. Immunoprecipitation of different pancreatic carcinoma cell lines showed that alpha(6) was expressed together with the beta(4) subunit as alpha(6) beta(4) complex. However, adhesion of pancreatic cancer cells to laminin could be inhibited with anti-alpha(6) and anti-beta(1) integrin antibodies but not by anti-beta(4) integrin antibody. Migration of the cells through laminin was almost completely inhibited by anti-beta(1) antibody but not by other anti-integrin antibodies. Tumor cell invasion through a reconstituted basement membrane was only slightly inhibited by anti-alpha(6) antibody. In contrast, a marked inhibition was observed using anti-beta(1) antibodies, anti-alpha(2)-anti-alpha(5) antibodies, and RGDS. Conclusions: The alpha(6)-containing integrin is a laminin adhesion receptor in pancreatic carcinoma cells, possibly involved in tumor invasion through the basement membrane.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 13:14:37