Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THERAPEUTIC EFFICACY OF 5-FLUOROURACIL PRODRUGS USING ENDOGENOUS SERUM-PROTEINS AS DRUG CARRIERS - A NEW STRATEGY IN DRUG-DELIVERY SYSTEM
Autore:
OKU N; YAMASHITA S; SAKURAGI N; DOI K; OKADA S; SHIMIDZU K; SUMI M; NADAI T; KUSUMOTO S; SUDA Y;
Indirizzi:
UNIV SHIZUOKA,SCH PHARMACEUT SCI,DEPT RADIOBIOCHEM YADA SHIZUOKA 422 JAPAN SETSUNAN UNIV,FAC PHARMACEUT SCI HIRAKATA OSAKA 57301 JAPAN OSAKA UNIV,FAC SCI,DEPT CHEM TOYONAKA OSAKA 560 JAPAN
Titolo Testata:
Biological & pharmaceutical bulletin
fascicolo: 1, volume: 18, anno: 1995,
pagine: 181 - 184
SICI:
0918-6158(1995)18:1<181:TEO5PU>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTITUMOR-ACTIVITY; BINDING POTENCIES; MICROSPHERES; DERIVATIVES; RELEASE;
Keywords:
DRUG DELIVERY; 5-FLUOROURACIL PRODRUG; LONG-CIRCULATING;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
N. Oku et al., "THERAPEUTIC EFFICACY OF 5-FLUOROURACIL PRODRUGS USING ENDOGENOUS SERUM-PROTEINS AS DRUG CARRIERS - A NEW STRATEGY IN DRUG-DELIVERY SYSTEM", Biological & pharmaceutical bulletin, 18(1), 1995, pp. 181-184

Abstract

To establish a novel drug delivery system for 5-fluorouracil (5FU), we have developed a system in which the low-molecular-weight prodrugs of 5FU bound to endogenous serum proteins, thus circulating like those proteins. Subsequently, the prodrugs were slowly hydrolyzed to generate active 5FU in the bloodstream. To examine the therapeutic effect of these prodrugs, we injected them into BALB/c mice previously implantedsubcutaneously with Meth A sarcoma. Among the prodrugs, 1-(N-4-chlorophenyl-N-methylcarbamoyl)-5 (5FU-1pCPMC) was effective in reducing tumors and prolonging survival time. The non-hydrolyzable compound, 1-(4-chlorobenzyl)-5-fluorouracil, did not show any therapeutic effect, suggesting that the therapeutic efficacy of 5FU-1pCPMC is due to the sustained release of 5FU from the serum protein-prodrug complex. The data shown here may create a new field in drug delivery system technology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:12:51