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Titolo:
EFFECTS OF ALKALOIDS EXTRACTED FROM THE STEM BARK OF HUNTERIA-ZEYLANICA ON ACUTE-INFLAMMATION IN EXPERIMENTAL-ANIMALS
Autore:
REANMONGKOL W; MATSUMOTO K; WATANABE H; SUBHADHIRASAKUL S; TAKAYAMA H; SAKAI SI;
Indirizzi:
TOYAMA MED & PHARMACEUT UNIV,WAKAN YAKU RES INST,DIV PHARMACOL,2360 SUGITANI TOYAMA 93001 JAPAN TOYAMA MED & PHARMACEUT UNIV,WAKAN YAKU RES INST,DIV PHARMACOL TOYAMA93001 JAPAN PRINCE SONGKLA UNIV,FAC PHARMACEUT SCI,DEPT PHARMACEUT BOT & PHARMACOGNOSY SONGKHLA 90112 THAILAND CHIBA UNIV,FAC PHARMACEUT SCI,DEPT PHARMACEUT CHEM CHIBA 263 JAPAN
Titolo Testata:
Biological & pharmaceutical bulletin
fascicolo: 1, volume: 18, anno: 1995,
pagine: 33 - 36
SICI:
0918-6158(1995)18:1<33:EOAEFT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PAW EDEMA; MOUSE EAR EDEMA; ARACHIDONIC-ACID; ANTIINFLAMMATORY AGENTS; INHIBITORS; DRUGS;
Keywords:
HUNTERIA ZEYLANICA; ACUTE INFLAMMATION; PAW EDEMA; EAR EDEMA; CYCLOOXYGENASE; 5-LIPOXYGENASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
W. Reanmongkol et al., "EFFECTS OF ALKALOIDS EXTRACTED FROM THE STEM BARK OF HUNTERIA-ZEYLANICA ON ACUTE-INFLAMMATION IN EXPERIMENTAL-ANIMALS", Biological & pharmaceutical bulletin, 18(1), 1995, pp. 33-36

Abstract

The effects of crude alkaloids extracted from the stem bark of Hunteria zeylanica GARD. (H. zeylanica) on acute inflammatory responses suchas carrageenin-induced paw edema in rats and croton oil- and arachidonic acid-induced ear edema in mice were investigated. Oral administration of H. zeylanica alkaloid extract (200-400 mg/kg) significantly suppressed the paw swelling induced by carrageenin. In the croton oil-induced ear edema, topically applied H. zeylanica alkaloid extract, at doses of 200 and 400 mg/ml, also significantly reduced ear edema. Moreover, the extract (50-200 mg/kg, p.o.) reduced in a dose-dependent manner the ear swelling induced by topically applied arachidonic acid (2 mg/ear). These results suggest that the inhibitory effects of H. zeylanica alkaloid extract on acute edema formation are partly due to inhibition of 5-lipoxygenase and cyclooxygenase activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:29:37