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Titolo:
AN IN-VITRO PROMOTING ROLE FOR HYDROGEN-PEROXIDE IN HUMAN SPERM CAPACITATION
Autore:
GRIVEAU JF; RENARD P; LELANNOU D;
Indirizzi:
CTR HOSP REG & UNIV RENNES,HOTEL DIEU,OUEST,CECOS,1 RUE COCHARDIERE F-35000 RENNES FRANCE GRAF RENNES FRANCE
Titolo Testata:
International journal of andrology
fascicolo: 6, volume: 17, anno: 1994,
pagine: 300 - 307
SICI:
0105-6263(1994)17:6<300:AIPRFH>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; SPONTANEOUS LIPID-PEROXIDATION; HUMAN-SPERMATOZOA; ACROSOME REACTION; HYPERACTIVATED MOTILITY; MAMMALIAN SPERMATOZOA; INVITRO CAPACITATION; HAMSTER SPERMATOZOA; FLAGELLAR MOTILITY; IDENTIFICATION;
Keywords:
ACROSOME REACTION; CATALASE; HYDROGEN PEROXIDE; REACTIVE OXYGEN SPECIES; SPERMATOZOA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Griveau et al., "AN IN-VITRO PROMOTING ROLE FOR HYDROGEN-PEROXIDE IN HUMAN SPERM CAPACITATION", International journal of andrology, 17(6), 1994, pp. 300-307

Abstract

A complex process of maturation called capacitation is an essential step for spermatozoa to fertilize oocytes. Recent studies have shown that reactive oxygen species (ROS) can enhance the capacitation of humanspermatozoa and sperm-zona interaction. We have investigated whether hydrogen peroxide (H2O2) could trigger capacitation of human spermatozoa and the acrosome reaction. The addition of catalase, a specific H2O2 scavenger, at the beginning of the capacitation process decreased the levels of both hyperactivation and induced-acrosome reaction whereascatalase added 15 min before the induction of the acrosome reaction by the calcium ionophore had no effect. Supplementation of the medium with H2O2 resulted in increased levels of hyperactivation and the acrosome reaction, whereas H2O2 added 15 min before induction of the acrosome reaction did not have any stimulatory effect. These results suggestthat H2O2 may be involved in the capacitation process of human spermatozoa but not in the acrosome reaction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 03:32:56