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Titolo:
INTERACTION OF THE EFFECTS OF DOMPERIDONE AND SUB-ANESTHETIC CONCENTRATIONS OF ISOFLURANE ON THE IMMEDIATE AND SUSTAINED HYPOXIC VENTILATORY RESPONSE IN HUMANS
Autore:
FOO IT; MARTIN SE; LEE RJ; DRUMMOND GB; WARREN PM;
Indirizzi:
CITY HOSP EDINBURGH,RAYNE LAB,GREENBANK DR EDINBURGH EH10 5SB MIDLOTHIAN SCOTLAND ROYAL INFIRM,DEPT MED,RAYNE LAB,RESP MED UNIT EDINBURGH MIDLOTHIAN SCOTLAND UNIV EDINBURGH,DEPT PUBL HLTH SERV EDINBURGH MIDLOTHIAN SCOTLAND UNIV EDINBURGH,DEPT ANAESTHET EDINBURGH MIDLOTHIAN SCOTLAND
Titolo Testata:
British Journal of Anaesthesia
fascicolo: 2, volume: 74, anno: 1995,
pagine: 134 - 140
SICI:
0007-0912(1995)74:2<134:IOTEOD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE ANTAGONIST; HEALTHY HUMANS; CAROTID-BODY; HALOTHANE; HYPERCAPNIA; ANESTHESIA; SEDATION;
Keywords:
ANESTHETICS VOLATILE, ISOFLURANE; HYPOXIA; VENTILATION, HYPOXIC RESPONSE; PHARMACOLOGY, DOMPERIDONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
I.T. Foo et al., "INTERACTION OF THE EFFECTS OF DOMPERIDONE AND SUB-ANESTHETIC CONCENTRATIONS OF ISOFLURANE ON THE IMMEDIATE AND SUSTAINED HYPOXIC VENTILATORY RESPONSE IN HUMANS", British Journal of Anaesthesia, 74(2), 1995, pp. 134-140

Abstract

Twenty normal male subjects with brisk hypoxic ventilatory responses were recruited and ventilatory responses to sustained isocapnic hypoxia (Sa(O2) 80.4 (SD 1.3)% for 20 min) were studied on separate days under four conditions: hypoxia alone, with or without domperidone, and 0.1 MAC of end-tidal isoflurane, with or without domperidone. Ventilatory variables were subjected to analysis of variance with estimation of the effects of isoflurane and domperidone, and their interaction. Isoflurane reduced the initial increase in ventilation significantly by 3.12 (95% confidence limits 1.69, 4.55) litre min(-1) (P < 0.05) and domperidone increased the initial increase in ventilation by 1.78 (0.35, 3.21) litre min(-1) (P < 0.05). Neither isoflurane nor domperidone affected the subsequent ventilatory decline. No interaction was found between these agents. These results confirm that 0.1 MAC of isoflurane suppressed the initial hypoxic ventilatory response but not the subsequent ventilatory decline when hypoxia was sustained. Domperidone offset the suppressive effect of isoflurane on the hypoxic ventilatory response but no interaction was detected.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:44:17