Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DEREGULATION OF TYROSINE KINASES IN A RAT MACROPHAGE TUMOR - ECTOPIC EXPRESSION OF LCK
Autore:
SRIDHAR TS; REMA V; SWARUP G; KHAR A;
Indirizzi:
CTR CELLULAR & MOLEC BIOL,UPPAL RD HYDERABAD 500007 ANDHRA PRADESH INDIA CTR CELLULAR & MOLEC BIOL HYDERABAD 500007 ANDHRA PRADESH INDIA
Titolo Testata:
International journal of oncology
fascicolo: 2, volume: 6, anno: 1995,
pagine: 487 - 492
SICI:
1019-6439(1995)6:2<487:DOTKIA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROUS-SARCOMA VIRUS; PROTEIN-KINASE; LYMPHOCYTES-T; CELL-LINES; GENE HCK; P56LCK; PHOSPHORYLATION; ANTIGEN; TRANSFORMATION; PURIFICATION;
Keywords:
TYROSINE KINASE; DEREGULATION; SPONTANEOUS MALIGNANCY; LCK; ECTOPIC EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
T.S. Sridhar et al., "DEREGULATION OF TYROSINE KINASES IN A RAT MACROPHAGE TUMOR - ECTOPIC EXPRESSION OF LCK", International journal of oncology, 6(2), 1995, pp. 487-492

Abstract

AK-5, a spontaneous rat macrophage tumor has 2-3 fold higher membrane-associated tyrosine kinase (TK) activity than normal peritoneal macrophages. lck, the lymphoid-specific TK, is expressed ectopically in AK-5. p56(lck), the protein product of lck, was detected in AK-5 by immunoprecipitation. The surface proteins CD4 and CD8 to which p56(lck) is complexed in lymphocytes are not present an the surface of AK-5. The transcripts of hck, a gene expressed predominantly in myeloid cells aremarkedly reduced in AK-5. The genomic organization of lck is unaltered. Although the total phosphotyrosine content of proteins is not altered significantly, there is a qualitative change in the profile of phosphotyrosine containing proteins. These results provide evidence for the ectopic expression of lck in a hematopoietic tumor and bolster the existing data implicating the participation of src family TKs in spontaneous neoplasms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:42:40