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Titolo:
DIFFERENT KINETICS OF TOLERANCE TO BEHAVIORAL AND ELECTROENCEPHALOGRAPHIC EFFECTS OF CHLORDIAZEPOXIDE IN THE RAT
Autore:
SALA M; LEONE MP; LAMPUGNANI P; BRAIDA D; GORI E;
Indirizzi:
UNIV MILAN,FAC MATH PHYS & NAT SCI,INST PHARMACOL,VIA VANVITELLI 32-AI-20129 MILAN ITALY
Titolo Testata:
European journal of pharmacology
fascicolo: 1-2, volume: 273, anno: 1995,
pagine: 35 - 45
SICI:
0014-2999(1995)273:1-2<35:DKOTTB>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE ANTAGONIST; PHYSICAL-DEPENDENCE; PHARMACODYNAMIC INTERACTION; LONG-TERM; DIAZEPAM; WITHDRAWAL; MIDAZOLAM; FLUMAZENIL; CLONAZEPAM; INDUCTION;
Keywords:
CHRONIC CHLORDIAZEPOXIDE; BEHAVIOR; EEG (ELECTROENCEPHALOGRAPHIC); TOLERANCE; DEPENDENCE; (RAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
M. Sala et al., "DIFFERENT KINETICS OF TOLERANCE TO BEHAVIORAL AND ELECTROENCEPHALOGRAPHIC EFFECTS OF CHLORDIAZEPOXIDE IN THE RAT", European journal of pharmacology, 273(1-2), 1995, pp. 35-45

Abstract

The daily oral administration of chlordiazepoxide (40 mg/kg) over 9 weeks in rats elicited full tolerance to muscle relaxant effects within7 weeks, as revealed by twice weekly evaluations of abdominal tone myorelaxation and decreased grip strength. No full tolerance was achieved, however, during the 9 weeks of treatment in terms of ataxia. Electroencephalographic (EEG) studies showed that this tolerance to the behavioural effects was accompanied by a progressive decrease in mean power spectra, associated with a progressive decrease in the beta band, but in this case, full tolerance was reached within 4 weeks. Once weeklyevaluations of the ability of chlordiazepoxide to protect the animalsagainst pentylenetetrazole seizures revealed a similar pattern. Treatment with flumazenil (50 mg/kg p.o.) 24 h after the last chlordiazepoxide administration induced a clear withdrawal syndrome associated withEEG changes which consisted of an increase in total power spectra associated with an increase in the delta band (in comparison with chlordiazepoxide-dependent rats not given the antagonist). These findings suggest that the different kinetics of the tolerance to anticonvulsant and EEG effects in comparison to myorelaxant effects can be attributed to a different involvement of benzodiazepine receptor subtypes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:17:29