Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SHARING OF THE IL-2 RECEPTOR-GAMMA CHAIN WITH THE FUNCTIONAL IL-9 RECEPTOR COMPLEX
Autore:
KIMURA Y; TAKESHITA T; KONDO M; ISHII N; NAKAMURA M; VANSNICK J; SUGAMURA K;
Indirizzi:
TOHOKU UNIV,SCH MED,DEPT MICROBIOL,AOBA KU,2-1 SEIRYO MACHI SENDAI MIYAGI 98077 JAPAN TOHOKU UNIV,SCH MED,DEPT MICROBIOL,AOBA KU SENDAI MIYAGI 98077 JAPAN LUDWIG INST CANC RES B-1200 BRUSSELS BELGIUM
Titolo Testata:
International immunology
fascicolo: 1, volume: 7, anno: 1995,
pagine: 115 - 120
SICI:
0953-8178(1995)7:1<115:SOTIRC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE COMBINED IMMUNODEFICIENCY; GROWTH-ENHANCING ACTIVITY; NECROSIS FACTOR-ALPHA; HUMAN T-CELLS; INTERLEUKIN-2 RECEPTOR; MONOCLONAL-ANTIBODY; EXPRESSION CLONING; MURINE THYMOCYTES; BETA-CHAIN; MOUSE;
Keywords:
ANTI-COMMON GAMMA CHAIN MAB; COMMON GAMMA CHAIN; XSCID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
Y. Kimura et al., "SHARING OF THE IL-2 RECEPTOR-GAMMA CHAIN WITH THE FUNCTIONAL IL-9 RECEPTOR COMPLEX", International immunology, 7(1), 1995, pp. 115-120

Abstract

The third subunit, the so-called common gamma (gamma(c)) chain, of the IL-2 receptor is shared among the receptors for IL-2, IL-4, IL-7 andIL-15, and dysfunction of the gamma(c) chain is thought to cause X-linked severe combined immunodeficiency (XSCID) ascribed to impairment of early T cell development. However, cytokines linked to XSCID are as yet unidentified. A mAb specific for the gamma(c) chain, TUGm2, profoundly inhibited cell proliferation in response to IL-9. Another mAb, TUGm3, immunoprecipitated [I-125]IL-9 cross-linked with either the IL-9 receptor or the gamma(c) chain. These results demonstrate that the gamma(c) chain is included in the functional receptor complex for IL-9, which was initially characterized as a T cell growth factor and is essential for IL-9-dependent growth signal transduction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 01:31:18