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Titolo:
ESCHERICHIA-COLI PEPTIDE METHIONINE SULFOXIDE REDUCTASE GENE - REGULATION OF EXPRESSION AND ROLE IN PROTECTING AGAINST OXIDATIVE DAMAGE
Autore:
MOSKOVITZ J; RAHMAN MA; STRASSMAN J; YANCEY SO; KUSHNER SR; BROT N; WEISSBACH H;
Indirizzi:
ROCHE INST MOLEC BIOL,ROCHE RES CTR NUTLEY NJ 07110 ROCHE INST MOLEC BIOL,ROCHE RES CTR NUTLEY NJ 07110 UNIV GEORGIA,DEPT GENET ATHENS GA 30602
Titolo Testata:
Journal of bacteriology
fascicolo: 3, volume: 177, anno: 1995,
pagine: 502 - 507
SICI:
0021-9193(1995)177:3<502:EPMSRG>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDIZED ALPHA-1-PROTEINASE INHIBITOR; ENZYMATIC REDUCTION; GROWTH-PHASE; TRANSCRIPTION; PROTEIN; CLONING; FLUID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J. Moskovitz et al., "ESCHERICHIA-COLI PEPTIDE METHIONINE SULFOXIDE REDUCTASE GENE - REGULATION OF EXPRESSION AND ROLE IN PROTECTING AGAINST OXIDATIVE DAMAGE", Journal of bacteriology, 177(3), 1995, pp. 502-507

Abstract

The Escherichia coli peptide methionine sulfoxide reductase gene (msrA) encodes a single subunit polypeptide of 212 amino acid residues (M,A, Rahman, H, Nelson, H, Weissbach, and N, Brot, J, Biol. Chem, 267:15549-15551, 1992), RNA blot analysis showed that the gene is transcribed into an mRNA of about 850 nucleotides, The promoter region was characterized, and the transcription initiation site was identified by primer extension. The synthesis of the MsrA protein increased about threefold in a growth-phase-dependent fashion, In an attempt to define the in vivo role of msrA, a chromosomal disruption was constructed. This mutant was more sensitive to oxidative stress, suggesting that oxidation of methionine in proteins plays an important role in oxidative damage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:41:40