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Titolo:
THE SIGMA-LIGAND BMY-14802 AS A POTENTIAL ANTIPSYCHOTIC - EVIDENCE FROM THE LATENT INHIBITION MODEL IN RATS
Autore:
WEINER I; TRAUB A; RAWLINS JNP; SMITH AD; FELDON J;
Indirizzi:
ETH ZURICH,INST TOXICOL,BEHAV BIOL & FUNCT TOXICOL,SCHORENSTR 16 CH-8603 SCHWERZENBACH SWITZERLAND ETH ZURICH,INST TOXICOL,BEHAV BIOL & FUNCT TOXICOL CH-8603 SCHWERZENBACH SWITZERLAND TEL AVIV UNIV,DEPT PSYCHOL,BEHAV NEUROSCI LAB IL-69978 TEL AVIV ISRAEL UNIV OXFORD,DEPT EXPTL PSYCHOL OXFORD OX2 3UD ENGLAND UNIV OXFORD,DEPT PHARMACOL OXFORD OX1 3QT ENGLAND
Titolo Testata:
Behavioural pharmacology
fascicolo: 1, volume: 6, anno: 1995,
pagine: 46 - 54
SICI:
0955-8810(1995)6:1<46:TSBAAP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC ATTENTION DISORDER; DOPAMINE NEURONAL-ACTIVITY; CHRONIC AMPHETAMINE; REAL-TIME; HALOPERIDOL; DRUG; FACILITATION; SENSITIVITY; INVOLVEMENT; HIPPOCAMPUS;
Keywords:
LATENT INHIBITION; BMY-14802; SIGMA LIGAND; AMPHETAMINE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
I. Weiner et al., "THE SIGMA-LIGAND BMY-14802 AS A POTENTIAL ANTIPSYCHOTIC - EVIDENCE FROM THE LATENT INHIBITION MODEL IN RATS", Behavioural pharmacology, 6(1), 1995, pp. 46-54

Abstract

Latent inhibition (LT) is a measure of retarded conditioning to a previously-presented nonreinforced stimulus, that is impaired in schizophrenic patients and in rats treated with amphetamine. Neuroleptic drugsare known to produce two effects in this test paradigm: to antagoniseamphetamine-induced disruption of LI, and to enhance LI when administered on their own. The present experiments tested the effects on LI ofa potential antipsychotic, sigma ligand BMY-14802. The experiments used a conditioned emotional response (CER) procedure in rats licking for water, consisting of three stages: preexposure, in which the to-be-conditioned stimulus (a tone) was repeatedly presented without being followed by reinforcement; conditioning, in which the preexposed stimulus was paired with reinforcement (a foot shock); and test, in which LI was indexed by animals' degree of suppression of licking during tone presentation. In Experiment 1, 20 tone preexposures and two conditioning trials were given and the effects of 5, 15, and 30 mg/kg BMY-14802 were assessed. Experiment 2 tested the effects of 15 and 30 mg/kg on LIusing ten preexposures and two conditioning trials. Experiment 3 investigated the effects of 15 and 30 mg/kg on LI using 40 preexposures and extended conditioning consisting of five tone-shock pairings. Experiments 4 and 5 investigated antagonism of amphetamine-induced disruption of LI by 15 and 30 mg/kg BMY-14802, respectively. BMY-14802 was found to antagonise amphetamine-induced disruption of LI and enhance LI when low numbers of preexposures and two conditioning trials were given,but not following extended conditioning. These results provide partial support for the suggestion that BMY-14802 may possess antipsychotic properties.

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Documento generato il 05/04/20 alle ore 09:06:53