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Titolo:
GLUTATHIONE-LINKED DRUG-RESISTANCE
Autore:
GOUYETTE A;
Indirizzi:
INST GUSTAVE ROUSSY,DEPT PHARMACOTOXICOL & PHARMACOGENET,CNRS,URA 147,RUE CAMILLE DESMOULINS F-94800 VILLEJUIF FRANCE
Titolo Testata:
Bulletin du cancer
, volume: 81, anno: 1994, supplemento:, 2
pagine: 69 - 73
SICI:
0007-4551(1994)81:<69:GD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
FRE
Soggetto:
METABOLIZING ENZYME-SYSTEMS; INHIBITOR ETHACRYNIC-ACID; HUMAN COLON TUMORS; CANCER CELL-LINE; S-TRANSFERASE-PI; LUNG-CANCER; BREAST-CANCER; PHASE-I; EXPRESSION; 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA;
Keywords:
DRUG RESISTANCE; GLUTATHIONE; GLUTATHIONE-S-TRANSFERASES; CHEMOTHERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A. Gouyette, "GLUTATHIONE-LINKED DRUG-RESISTANCE", Bulletin du cancer, 81, 1994, pp. 69-73

Abstract

Several mechanisms of resistance (of bacteria to antibiotics, of plants to herbicides, of insects to insecticides, of cancer cells to cytotoxic agents...) have now been described. The most studied one is the glycoprotein coded by the mdr1 gene, which is involved in the efflux ofnumerous compounds of natural origin (anthracyclins, podophyllotoxins...) thus decreasing the intracellular concentration of such drugs. Nevertheless, many chemotherapeutic protocols include alkylating agents,such as cyclophosphamide and cisplatin, which are electrophilic species prone to react readily with the tripeptide glutathione, most often through glutathione-S-transferases. Therefore, it appears of major importance to evaluate the role of glutathione and that of the polymorphism of the glutathione-S-transferases, as prognostic factors in the response to chemotherapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:22:08