Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NERVE GROWTH-FACTOR PROMOTES NEURITE REGENERATION IN PC12 CELLS BY TRANSLATIONAL CONTROL
Autore:
TWISS JL; SHOOTER EM;
Indirizzi:
STANFORD UNIV,SCH MED,DEPT NEUROBIOL,D225,300 PASTEUR DR STANFORD CA 94305 STANFORD UNIV,SCH MED,DEPT PATHOL STANFORD CA 94305
Titolo Testata:
Journal of neurochemistry
fascicolo: 2, volume: 64, anno: 1995,
pagine: 550 - 557
SICI:
0022-3042(1995)64:2<550:NGPNRI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA STABILITY; GAP-43 GENE-EXPRESSION; CONDITIONING LESION; PROTEIN-SYNTHESIS; NEURONAL DIFFERENTIATION; PHEOCHROMOCYTOMA CELLS; SYMPATHETIC NEURONS; FACTOR WITHDRAWAL; SCIATIC-NERVE; CYCLIC-AMP;
Keywords:
NERVE GROWTH FACTOR; NEUROTROPHIC FACTORS; PC12 CELLS; NEURONAL REGENERATION; POSTTRANSCRIPTIONAL MECHANISMS; TRANSLATIONAL CONTROL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Twiss e E.M. Shooter, "NERVE GROWTH-FACTOR PROMOTES NEURITE REGENERATION IN PC12 CELLS BY TRANSLATIONAL CONTROL", Journal of neurochemistry, 64(2), 1995, pp. 550-557

Abstract

When PC12 cells are primed with nerve growth factor (NGF) for periodsof greater than or equal to 1 week, they acquire the ability to regenerate neurites rapidly in response to NGF. It is not known how NGF promotes this regeneration, but it does not require ongoing RNA synthesis. Previous studies have suggested that NGF directs the accumulation ofprecursor molecules that are rapidly assembled to form the regenerated neurites. To address the nature of these precursor molecules, we have treated PC12 cells with macromolecular synthesis inhibitors during the priming and regeneration phases of neurite growth. Here we show that NGF promotes neurite regeneration by inducing the synthesis of new proteins. These proteins are encoded by short-lived mRNAs that are generated during the NGF priming period. The isolation and identification of these mRNAs will allow a further understanding of how NGF promotes neurite regeneration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 08:19:54