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Titolo:
SPECT REGIONAL CEREBRAL BLOOD-FLOW ALTERATIONS IN NALTREXONE-PRECIPITATED WITHDRAWAL FROM BUPRENORPHINE
Autore:
VANDYCK CH; ROSEN MI; THOMAS HM; MCMAHON TJ; WALLACE EA; OCONNOR PG; SULLIVAN M; KRYSTAL JH; HOFFER PB; WOODS SW; KOSTEN TR;
Indirizzi:
YALE UNIV,SCH MED,DEPT PSYCHIAT,CB2041,333 CEDAR ST NEW HAVEN CT 06510 YALE UNIV,SCH MED,DEPT MED NEW HAVEN CT 06510
Titolo Testata:
Psychiatry research
fascicolo: 4, volume: 55, anno: 1994,
pagine: 181 - 191
SICI:
0165-1781(1994)55:4<181:SRCBAI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; BRAIN GLUCOSE-METABOLISM; MORPHINE-WITHDRAWAL; HEROIN-ADDICTS; NALOXONE; RAT; PAIN; 2-DEOXYGLUCOSE; DEPENDENCE; METHADONE;
Keywords:
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SUBSTANCE DEPENDENCE; OPIATE WITHDRAWAL; CINGULATE CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
C.H. Vandyck et al., "SPECT REGIONAL CEREBRAL BLOOD-FLOW ALTERATIONS IN NALTREXONE-PRECIPITATED WITHDRAWAL FROM BUPRENORPHINE", Psychiatry research, 55(4), 1994, pp. 181-191

Abstract

The effects of naltrexone-precipitated withdrawal from buprenorphine on behavior and regional cerebral blood now (rCBF) were studied in 11 opiate-dependent patients. Patients initially received buprenorphine, 2 mg sublingually, every day for 7 days. They were then challenged sequentially with placebo and naltrexone, 25 mg orally, before single photon emission computed tomography with technetium-(99)m-d,l-hexamethyl-propylene amine oxime as tracer. Behavioral ratings of withdrawal severity were made before and after naltrexone/placebo administration. Naltrexone produced significantly greater signs and symptoms of opiate withdrawal than placebo. Analysis of variance revealed no significant regionally specific effect of naltrexone on rCBF ratios. Severity of withdrawal, however, showed a significant negative correlation with rCBF in the anterior cingulate cortex following naltrexone. These results are interesting as the anterior cingulate region has been implicated inthe emotional component of pain and in opiate-induced analgesia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:40:59