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Titolo:
VARIED EXPRESSION OF MAJOR HISTOCOMPATIBILITY COMPLEX AND ONCOGENES IN SHOPE CARCINOMA CELL-LINES DERIVED FROM A SINGLE TUMOR
Autore:
KIM CJ; TOMOYOSHI T; SETO A;
Indirizzi:
SHIGA UNIV MED SCI,DEPT MICROBIOL OTSU SHIGA 52021 JAPAN SHIGA UNIV MED SCI,DEPT UROL OTSU SHIGA 52021 JAPAN
Titolo Testata:
Journal of cancer research and clinical oncology
fascicolo: 1, volume: 121, anno: 1995,
pagine: 16 - 22
SICI:
0171-5216(1995)121:1<16:VEOMHC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-EXPRESSION; NUCLEOTIDE-SEQUENCE; ANTIGEN EXPRESSION; RAT-CELLS; RABBIT; ADENOVIRUS-12; PAPILLOMAS;
Keywords:
MAJOR HISTOCOMPATIBILITY COMPLEX; ONCOGENE SQUAMOUS CELL CARCINOMA; PAPILLOMAVIRUS; RABBIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
C.J. Kim et al., "VARIED EXPRESSION OF MAJOR HISTOCOMPATIBILITY COMPLEX AND ONCOGENES IN SHOPE CARCINOMA CELL-LINES DERIVED FROM A SINGLE TUMOR", Journal of cancer research and clinical oncology, 121(1), 1995, pp. 16-22

Abstract

The cellular gene expression was compared in four Shope carcinoma cell lines, which were derived from a single tumor and possess various potentials for differentiation and tumorigenicity. The E6 and E7 transforming genes of cottontail rabbit papillomavirus were expressed in all these cell lines, highest level of expression being in the most tumorigenic and undifferentiated cell line, where the major histocompatibility complex (MHC) class I expression was the lowest. The MHC class II antigen, which is not expressed on normal epithelial cells, was detected in all the cell lines, but hardly, if at all, on the surface of these cells. The surface expression of the MHC class TI antigen could not be induced by the culture supernatant of phytohaemaglutinin-stimulatedsplenocytes, which increased the surface expression level of the MHC class I antigen of the same cells. These findings suggest that the aberrant expression of the MHC class II antigen in these cells could not be implicated in the immune response against tumors. The c-fos, c-myc and c-H-ras oncogenes were variably expressed in these cell Lines, butthere was no correlation with tumorigenicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:06:35