Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NEW MOUSE MODEL FOR POLYCYSTIC KIDNEY-DISEASE WITH BOTH RECESSIVE ANDDOMINANT GENE EFFECTS
Autore:
FLAHERTY L; BRYDA EC; COLLINS D; RUDOFSKY U; MONTGOMERY JC;
Indirizzi:
NEW YORK STATE DEPT HLTH,WADSWORTH CTR,DEV GENET LAB,MOLEC GENET PROGRAM,NEW SCOTLAND AVE ALBANY NY 12201 NEW YORK STATE DEPT HLTH,WADSWORTH CTR,IMMUNOL & PATHOL LAB ALBANY NY12201
Titolo Testata:
Kidney international
fascicolo: 2, volume: 47, anno: 1995,
pagine: 552 - 558
SICI:
0085-2538(1995)47:2<552:NMMFPK>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSGENIC MICE; MURINE MODEL; EARLY REGION; CPK MOUSE; MUTATIONS; ONCOGENE; MAP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
L. Flaherty et al., "NEW MOUSE MODEL FOR POLYCYSTIC KIDNEY-DISEASE WITH BOTH RECESSIVE ANDDOMINANT GENE EFFECTS", Kidney international, 47(2), 1995, pp. 552-558

Abstract

In the course of studying the genetics of chlorambucil mutagenesis, we have uncovered a new model for autosomal polycystic kidney disease (PKD). In the homozygous condition, the gene, jcpk, causes a very severe disease characterized by cysts in all segments of the nephron. Deathusually occurs before 10 days of age. Extrarenal involvement was alsonoted; enlarged bile ducts, pancreatic ducts, and gall bladder often accompanied the PKD. In addition, approximately 25% of the aged +/jcpkheterozygotes show evidence of glomerulocystic disease. This gene maps to Chromosome 10 between two DNA markers, D10Mit20 and D10Mit42. Because this gene causes extrarenal abnormalities and because it has a heterozygote effect, it may be an informative animal model for the commonly occurring human adult dominant PKD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 05:43:18