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Titolo:
INDUCTION OF PROTECTION AGAINST BORNA-DISEASE BY INOCULATION WITH HIGH-DOSE-ATTENUATED BORNA-DISEASE VIRUS
Autore:
OLDACH D; ZINK MC; PYPER JM; HERZOG S; ROTT R; NARAYAN O; CLEMENTS JE;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT COMPARAT MED BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT COMPARAT MED BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT PATHOL BALTIMORE MD 21205 UNIV MARYLAND,SCH MED,DEPT INFECT DIS BALTIMORE MD 21201 UNIV GIESSEN,INST VIROL W-6300 GIESSEN GERMANY UNIV KANSAS,MED CTR,DEPT MICROBIOL KANSAS CITY KS 66160
Titolo Testata:
Virology
fascicolo: 1, volume: 206, anno: 1995,
pagine: 426 - 434
SICI:
0042-6822(1995)206:1<426:IOPABB>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFECTED-RATS; SCHWANN-CELLS; PATHOGENESIS; REPLICATION; AGENT; ASTROCYTES; PROTEINS; ANTIGEN; TISSUES; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
D. Oldach et al., "INDUCTION OF PROTECTION AGAINST BORNA-DISEASE BY INOCULATION WITH HIGH-DOSE-ATTENUATED BORNA-DISEASE VIRUS", Virology, 206(1), 1995, pp. 426-434

Abstract

Borna disease is a chronic neurological disease caused by an enveloped negative-strand RNA virus (BDV). Experimental disease can be reproduced in rats with brain homogenates derived from infected animals or with virus derived from infected cells in culture. The virus replicates in cultured cells without evidence of cytopathic effect or production of significant levels of cell-free virus. Borna disease is caused by an immunopathological response to viral infection of neural cells. To further investigate the pathogenesis of Borna disease, rats were inoculated with different doses of BDV attenuated by culture in MDCK cells. Low doses of attenuated BDV (10(2)-10(4) TCID50) resulted in typical clinical disease and severe encephalitis; however, the lag period between inoculation and disease was considerably longer than that with virulent BDV. In contrast, animals inoculated with a high dose of attenuated BDV (10(5)-10(6) TCID50) did not develop clinical disease, althougha mild encephalitic response was present that did not progress beyondthe mild encephalitis. Animals inoculated with a high dose of BDV developed high titers of anti-BDV antibody and were protected against virulent challenge. Protection was correlated with the rapid induction ofan immune response in the animals and the lack of any biologically detectable virus in the CNS. (C) 1995 Academic Press, Inc.

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Documento generato il 20/01/20 alle ore 16:49:35