Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DISCREPANCY BETWEEN THE NEPHROTOXIC POTENCIES OF CADMIUM-METALLOTHIONEIN AND CADMIUM CHLORIDE AND THE RENAL CONCENTRATION OF CADMIUM IN THEPROXIMAL CONVOLUTED TUBULES
Autore:
DORIAN C; GATTONE VH; KLAASSEN CD;
Indirizzi:
UNIV KANSAS,MED CTR,DEPT PHARMACOL KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT PHARMACOL KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT TOXICOL & THERAPEUT KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT ANAT & CELL BIOL KANSAS CITY KS 66160
Titolo Testata:
Toxicology and applied pharmacology
fascicolo: 1, volume: 130, anno: 1995,
pagine: 161 - 168
SICI:
0041-008X(1995)130:1<161:DBTNPO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOXICITY; KIDNEY; NEPHROPATHY; BINDING; INJURY; GLUTATHIONE; PROTEIN; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
C. Dorian et al., "DISCREPANCY BETWEEN THE NEPHROTOXIC POTENCIES OF CADMIUM-METALLOTHIONEIN AND CADMIUM CHLORIDE AND THE RENAL CONCENTRATION OF CADMIUM IN THEPROXIMAL CONVOLUTED TUBULES", Toxicology and applied pharmacology, 130(1), 1995, pp. 161-168

Abstract

Acute exposure to inorganic cadmium produces hepatotoxicity, but no renal injury. In contrast, chronic exposure to Cd produces nephrotoxic effects. However, a single injection of cadmium bound to metallothionein (CdMT) can produce nephrotoxicity similar to that seen with chronicexposure to Cd. It is generally thought that CdMT is nephrotoxic because more CdMT than CdCl2 distributes to the kidney. To test this hypothesis, the toxic effects and distribution of Cd were compared after ivinjection of CdMT and CdCl2 to mice. CdMT increased urinary excretionof glucose, and protein indicating renal injury. This dysfunction occurred with dosages as low as 0.2 mg Cd/kg. In contrast, renal functionwas unaltered by CdCl2 administration, even at dosages as high as 3 mg Cd/kg. CdMT distributed almost exclusively to the kidney, whereas CdCl2 preferentially distributed to the liver. However, a high concentration of Cd was also found in the kidneys after CdCl2 administration. In fact, the renal Cd concentration after administration of a high but nonnephrotoxic dose of CdCl2 was equal to or higher than that obtainedafter injection of nephrotoxic doses of CdMT. Light microscopic autoradiography studies, using 0.3 mg Cd/kg as CdMT and 3 mg Cd/kg as CdCl2, indicated that Cd from CdMT preferentially distributed to the convoluted segments (S1 and S2) of the proximal tubules, whereas Cd from CdCl2 distributed equally to the various segments (convoluted and straight) of the proximal tubules. However, the concentration of Cd at the site of nephrotoxicity, the proximal convoluted tubules, was higher after CdCl2 than after CdMT administration. A higher Cd concentration in both apical and basal parts of the proximal cells was found after CdCl2than after CdMT administration. Therefore, the reason why CdMT is nephrotoxic and CdCl2 is not nephrotoxic is not due to a higher concentration of Cd in the target cells after CdMT than after CdCl2 administration. (C) 1995 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 01:53:05