Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
STRUCTURAL AND FUNCTIONAL-STUDIES OF THE INTRACELLULAR TYROSINE KINASE MATK GENE AND ITS TRANSLATED PRODUCT
Autore:
AVRAHAM S; JIANG SX; OTA S; FU YG; DENG BJ; DOWLER LL; WHITE RA; AVRAHAM H;
Indirizzi:
HARVARD UNIV,NEW ENGLAND DEACONESS HOSP,SCH MED,DIV HEMATOL ONCOL,1 DEACONESS RD BOSTON MA 02215 HARVARD UNIV,NEW ENGLAND DEACONESS HOSP,SCH MED,DIV HEMATOL ONCOL BOSTON MA 02215 UNIV MISSOURI,CHILDRENS MERCY HOSP,SCH MED,GENET SECT KANSAS CITY MO 64108
Titolo Testata:
The Journal of biological chemistry
fascicolo: 4, volume: 270, anno: 1995,
pagine: 1833 - 1842
SICI:
0021-9258(1995)270:4<1833:SAFOTI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
X-LINKED AGAMMAGLOBULINEMIA; CELL ANTIGEN RECEPTOR; SRC FAMILY KINASES; GROWTH-FACTOR; SIGNAL TRANSDUCTION; HUMAN HEMATOPOIESIS; PROTEIN; EXPRESSION; MOUSE; CSK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
S. Avraham et al., "STRUCTURAL AND FUNCTIONAL-STUDIES OF THE INTRACELLULAR TYROSINE KINASE MATK GENE AND ITS TRANSLATED PRODUCT", The Journal of biological chemistry, 270(4), 1995, pp. 1833-1842

Abstract

We recently cloned the cDNA which encodes a novel megakaryocyte-associated tyrosine kinase termed MATK. In this study, we have cloned and characterized the human MATK gene as well as the murine homolog of human MATK cDNA and performed functional studies of its translated product, Comparison of the deduced amino acid sequences of human and murine MATK cDNAs revealed 85% homology, indicating that MATK is highly conserved in mouse and human, The human gene consists of 13 exons interrupted by 12 introns, The genetic units which encode the SH3 and SH2 domains are located on separate exons, The putative ATP binding site (GXGXXG) is localized on exon 7, and the entire catalytic domain is subdivided into seven exons (7-13), Somatic cell hybrid analysis indicated thathuman MATK gene is located on chromosome 19 while the murine Math gene is located on chromosome 10, The immediate 5'-flanking region was highly rich in GC sequences, and potential cis-acting elements were identified including several SP1, GATA-1, APRE, and APRE1, Antisense oligonucleotides directed against MATK mRNA sequences significantly inhibited megakaryocyte progenitor proliferation, Functional studies indicated that MATK can phosphorylate the carboxyl-terminal conserved tyrosineof the Src protein, These results support the notion that MATK acts as a regulator of p60(c-src) in megakaryocytic cells and participates in the pathways regulating growth of cells of this lineage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:39:03