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Titolo:
PANCREATIC DEVELOPMENT AND MATURATION OF THE ISLET B-CELL - STUDIES OF PLURIPOTENT ISLET CULTURES
Autore:
MADSEN OD; JENSEN J; BLUME N; PETERSEN HV; LUND K; KARLSEN C; ANDERSEN FG; JENSEN PB; LARSSON LI; SERUP P;
Indirizzi:
HAGEDORN RES LAB,NIELS STEENSENS VEJ 6 DK-2820 GENTOFTE DENMARK STATE SERUM INST,DEPT MOL CELL BIOL COPENHAGEN DENMARK
Titolo Testata:
European journal of biochemistry
fascicolo: 3, volume: 242, anno: 1996,
pagine: 435 - 445
SICI:
0014-2956(1996)242:3<435:PDAMOT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN INSULIN GENE; TISSUE-SPECIFIC REGULATION; ENHANCER-BINDING PROTEINS; DEVELOPING MOUSE PANCREAS; NEONATAL RAT PANCREAS; HUMAN FETAL PANCREAS; TRANSGENIC MICE; BETA-CELLS; TRANSCRIPTION FACTOR; GLUCOSE-TRANSPORTER;
Keywords:
ISLET; PANCREAS; INSULIN; B CELL; INSULIN-PROMOTER FACTOR 1;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
126
Recensione:
Indirizzi per estratti:
Citazione:
O.D. Madsen et al., "PANCREATIC DEVELOPMENT AND MATURATION OF THE ISLET B-CELL - STUDIES OF PLURIPOTENT ISLET CULTURES", European journal of biochemistry, 242(3), 1996, pp. 435-445

Abstract

Pancreas organogenesis is a highly regulated process, in which two anlage evaginate from the primitive gut. They later fuse, and, under theinfluence of the surrounding mesenchyme, the mature organ develops, being mainly composed of ductal, exocrine and endocrine compartments. Early buds are characterized by a branching morphogenesis of the ductalepithelium from which endocrine and exocrine precursor cells bud to eventually form the two other compartments. The three compartments are thought to be of common endodermal origin; in contrast to earlier hypotheses, which suggested that the endocrine compartment was of neuroectodermal origin. It is thus generally believed that the pancreatic endocrine-lineage possesses the ability to mature along a differentiation pathway that shares many characteristics with those of neuronal differentiation. During recent years, studies of insulin-gene regulation and, in particular, the tissue-specific transcriptional control of insulin-gene activity have provided information on pancreas development in general. The present review summarizes these findings, with a special focus on our own studies on pluripotent endocrine cultures of rat pancreas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 12:46:19