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Titolo:
PERIPHERAL HYPERALGESIA IN EXPERIMENTAL NEUROPATHY - EXACERBATION BY NEUROPEPTIDE-Y
Autore:
TRACEY DJ; ROMM MA; YAO NNL;
Indirizzi:
UNIV NEW S WALES,SCH ANAT SYDNEY NSW 2052 AUSTRALIA
Titolo Testata:
Brain research
fascicolo: 2, volume: 669, anno: 1995,
pagine: 245 - 254
SICI:
0006-8993(1995)669:2<245:PHIEN->2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
REFLEX SYMPATHETIC DYSTROPHY; SCIATIC-NERVE INJURY; RAT SENSORY NEURONS; NORADRENALINE HYPERALGESIA; VASOCONSTRICTOR AGENTS; CALCIUM CURRENT; PAIN; RECEPTORS; MODEL; MONONEUROPATHY;
Keywords:
PERIPHERAL NEUROPATHY; HYPERALGESIA; NEUROPEPTIDE Y; SYMPATHETIC NERVOUS SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Tracey et al., "PERIPHERAL HYPERALGESIA IN EXPERIMENTAL NEUROPATHY - EXACERBATION BY NEUROPEPTIDE-Y", Brain research, 669(2), 1995, pp. 245-254

Abstract

Injury of peripheral nerves often results in hyperalgesia (an increased sensitivity to painful stimuli). This hyperalgesia is mediated in part by sympathetic neurotransmitters. We examined the effect of neuropeptide Y (NPY), specific Y1 and Y2 agonists, and an NPY antagonist on peripheral hyperalgesia in rats whose sciatic nerves had been partially transected. NPY and the Y2 agonist, N-acetyl [Leu(28),Leu(31)] NPY 24-36 exacerbated both mechanical and thermal hyperalgesia, while the Y1 agonist, [Leu(31), Pro(34)]NPY relieved thermal hyperalgesia. Mechanical and thermal hyperalgesia were both relieved by alpha-trinositol (PP56), a non-competitive antagonist of the actions of neuropeptide Y. Hyperalgesia was also relieved by surgical sympathectomy, which eliminated the effects of NPY and its agonists. These results suggest that neuropeptide Y contributes to peripheral hyperalgesia by actions at Y2 receptors, which may be located on postganglionic sympathetic terminals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:29:23