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Titolo:
APPLYING BAILER METHOD FOR AUC CONFIDENCE-INTERVALS TO SPARSE SAMPLING
Autore:
NEDELMAN JR; GIBIANSKY E; LAU DTW;
Indirizzi:
SANDOZ PHARMACEUT CORP,SANDOZ RES INST,DEPT CLIN PHARMACOL,59 ROUTE 10 E HANOVER NJ 07936 SANDOZ PHARMACEUT CORP,SANDOZ RES INST,DEPT DRUG SAFETY E HANOVER NJ 07936 SANDOZ PHARMACEUT CORP,SANDOZ RES INST,DEPT DRUG METAB & PHARMACOKINET E HANOVER NJ 07936
Titolo Testata:
Pharmaceutical research
fascicolo: 1, volume: 12, anno: 1995,
pagine: 124 - 128
SICI:
0724-8741(1995)12:1<124:ABMFAC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
VARIANCE;
Keywords:
AREA UNDER THE CURVE; DEGREES OF FREEDOM; SATTERTHWAITES APPROXIMATION; VARIANCE FUNCTION; TOXICOKINETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
5
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Nedelman et al., "APPLYING BAILER METHOD FOR AUC CONFIDENCE-INTERVALS TO SPARSE SAMPLING", Pharmaceutical research, 12(1), 1995, pp. 124-128

Abstract

Bailer (1) developed a method for constructing confidence intervals for areas under the concentration-vs-time curve (AUC's) with only one sample per subject but with multiple subjects sampled at each of several time points post dose. We have modified this method to account for estimation of the variances. How the need to estimate variances affectsstudy design is discussed. An extension of Bailer's method is proposed where variances are modeled as a function of the means, in order to get more precise estimates of variances. The modified and extended methods are applied to a rat toxicokinetic study with only two rats per time point per treatment group.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 19:19:49