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Titolo:
PEPTIDE YY INHIBITS EXOCRINE PANCREATIC-SECRETION IN ISOLATED-PERFUSED RAT PANCREAS BY Y1 RECEPTORS
Autore:
GRANDT D; SIEWERT J; SIEBURG B; ALTAI O; SCHIMICZEK M; GOEBELL H; LAYER P; EYSSELEIN VE; REEVE JR; MULLER MK;
Indirizzi:
UNIV ESSEN GESAMTHSCH KLINIKUM,MED KLIN,GASTROENTEROL ABT,HUFELANDSTR55 D-45147 ESSEN GERMANY UNIV ESSEN GESAMTHSCH,DEPT GASTROENTEROL ESSEN GERMANY UNIV MANNHEIM,DEPT MED 4 W-6800 MANNHEIM GERMANY UNIV CALIF LOS ANGELES,HARBOR MED CTR,DEPT GASTROENTEROL TORRANCE CA 90509 UNIV CALIF LOS ANGELES,VET ADM WADSWORTH MED CTR,CTR ULCER RES & EDUC,DEPT MED LOS ANGELES CA 90073
Titolo Testata:
Pancreas
fascicolo: 2, volume: 10, anno: 1995,
pagine: 180 - 186
SICI:
0885-3177(1995)10:2<180:PYIEPI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPEPTIDE-Y; BLOOD-FLOW; INSULIN-SECRETION; STRUCTURAL CHARACTERIZATION; GASTROINTESTINAL-TRACT; GLUCAGON-SECRETION; ENDOCRINE PANCREAS; ANESTHETIZED DOG; SMOOTH-MUSCLE; PYY;
Keywords:
PEPTIDE YY (PYY); PYY 3-36; [PRO(34)]PYY; Y1 RECEPTOR; ISOLATED PERFUSED PANCREAS; EXOCRINE PANCREATIC SECRETION; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
D. Grandt et al., "PEPTIDE YY INHIBITS EXOCRINE PANCREATIC-SECRETION IN ISOLATED-PERFUSED RAT PANCREAS BY Y1 RECEPTORS", Pancreas, 10(2), 1995, pp. 180-186

Abstract

Peptide YY (PYY) inhibits exocrine pancreatic secretion in several species. Two receptors, Y1 and Y2, are known to mediate PYY actions. While PYY 1-36 binds equally to both receptor subtypes, a second endogenous form of PYY, PYY 3-36, selectively activates Y2 receptors. The importance of Y receptor subtypes for inhibition of exocrine pancreatic secretion by PYY is unknown. We studied the effects of PYY 1-36 on cholecystokinin octapeptide (CCK-8)-stimulated amylase secretion in an isolated perfused rat pancreas model. To characterize functionally the receptors involved we determined the effects of a Y1-selective agonist, [Pro(34)]PYY; a Y2 selective agonist, PYY 3-36; and neuropeptide Y (NPY) in this model. PYY 1-36 significantly inhibited stimulated amylase secretion in the denervated rat pancreas. [Pro(34)]PYY and NPY both inhibited exocrine pancreatic secretion as potently as PYY 1-36. Contraryto that, the Y2 selective agonist, PYY 3-36, was inactive. We conclude that PYY inhibits exocrine pancreatic secretion in this extrinsically denervated rat pancreas model by Y1 receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 06:04:31