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Titolo:
DIFFERENT INHIBITORY EFFECTS OF THE NEWLY DEVELOPED CCK RECEPTOR ANTAGONISTS FK480 AND KSG-504 ON PANCREATIC EXOCRINE AND ENDOCRINE SECRETION IN THE ISOLATED-PERFUSED RAT PANCREAS
Autore:
KIHARA Y; OTSUKI M;
Indirizzi:
UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT INTERNAL MED 3,YAHATANISHI KU,1-1 ISEIGAOKA KITAKYUSHU FUKUOKA 807 JAPAN UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT INTERNAL MED 3,YAHATANISHI KU KITAKYUSHU FUKUOKA 807 JAPAN
Titolo Testata:
Pancreas
fascicolo: 2, volume: 10, anno: 1995,
pagine: 109 - 117
SICI:
0885-3177(1995)10:2<109:DIEOTN>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOGENOUS CHOLECYSTOKININ; PROGLUMIDE ANALOG; INSULIN RELEASE; REGENERATION; POLYPEPTIDE; LOXIGLUMIDE; INVOLVEMENT; L-364,718; BLOCKADE; CR-1392;
Keywords:
CHOLECYSTOKININ RECEPTOR ANTAGONIST; FK480; KSG-504; INSULIN RELEASE; EXOCRINE PANCREATIC SECRETION; ISOLATED PERFUSED RAT PANCREAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
Y. Kihara e M. Otsuki, "DIFFERENT INHIBITORY EFFECTS OF THE NEWLY DEVELOPED CCK RECEPTOR ANTAGONISTS FK480 AND KSG-504 ON PANCREATIC EXOCRINE AND ENDOCRINE SECRETION IN THE ISOLATED-PERFUSED RAT PANCREAS", Pancreas, 10(2), 1995, pp. 109-117

Abstract

Cholecystokinin (CCK) receptor antagonists are shown to have therapeutic as well as preventive effects in some types of acute pancreatitis. However, there is a possibility that administration of CCK receptor antagonists with a high inhibitory potency on the endocrine pancreas topatients with acute pancreatitis exacerbates the associated glucose intolerance. In the present study we simultaneously examined the effects of the newly developed benzodiazepine derivative FK480 and proglumide-related antagonist KSG-504 on CCK octapeptide (CCK-8)-stimulated exocrine and endocrine function in the isolated perfused rat pancreas. FK480 and KSG-504 inhibited CCK-8-stimulated pancreatic juice flow, protein output, and insulin release in a dose-dependent manner. FK480 was approximately 10 times more potent than KSG-504 in inhibiting exocrineand endocrine secretion. Both antagonists inhibited CCK-8-stimulated insulin release more potently than exocrine secretion. FK480 caused a dose-dependent residual inhibition of exocrine secretion after its removal from the perfusate, whereas insulin release was only slightly impaired even at the highest dose. In contrast, termination of KSG-504 infusion resulted in an immediate increase in both exocrine and insulin responses without causing any residual inhibition. With regard to the residual inhibition, therefore, KSG-504 had no significant influences on exocrine and insulin release, whereas FK480 inhibited exocrine secretion more potently than insulin response. These results suggest that FK480 might become a useful therapeutic agent for pancreatitis with respect to its long-duration inhibitory effect on exocrine secretion andshort-duration inhibitory effect on insulin release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:14:30