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Titolo:
THE X-PROTEIN OF HEPATITIS-B VIRUS COACTIVATES POTENT ACTIVATION DOMAINS
Autore:
HAVIV I; VAIZEL D; SHAUL Y;
Indirizzi:
WEIZMANN INST SCI,DEPT MOLEC GENET & VIROL IL-76100 REHOVOT ISRAEL WEIZMANN INST SCI,DEPT MOLEC GENET & VIROL IL-76100 REHOVOT ISRAEL
Titolo Testata:
Molecular and cellular biology
fascicolo: 2, volume: 15, anno: 1995,
pagine: 1079 - 1085
SICI:
0270-7306(1995)15:2<1079:TXOHVC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA POLYMERASE-II; NF-KAPPA-B; EUKARYOTIC TRANSCRIPTIONAL ACTIVATORS; HUMAN-IMMUNODEFICIENCY-VIRUS; TATA-BINDING PROTEIN; LONG TERMINAL REPEAT; GENE-PRODUCT; DNA-BINDING; C-JUN; TRANS-ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
90
Recensione:
Indirizzi per estratti:
Citazione:
I. Haviv et al., "THE X-PROTEIN OF HEPATITIS-B VIRUS COACTIVATES POTENT ACTIVATION DOMAINS", Molecular and cellular biology, 15(2), 1995, pp. 1079-1085

Abstract

Transactivation by hepatitis B virus X protein (pX) is promiscuous, but it requires cellular activators. To study the mode of action of pX,we coexpressed pX with Gal4-derived activators in a cotransfection system. Twelve different activators bearing different types of activation domains were compared for their response to pX. Because pX indirectly increases the amount of the activators, tools were developed to compare samples with equivalent amount of activators. We demonstrate that pX preferentially coactivates potent activators, especially those withacidic activation domains. Weak activators with nonacidic activation domains are not potentiated by pX. Interestingly, Gal4E1a, which is not rich in acidic residues but interacts with similar molecular targets, also responds to pX. The response to pX correlated with the strengthof the activation domain. Collectively, these data imply that pX is acoactivator, which offers a molecular basis for the pleiotropic effects of pX on transcription.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:59:36