Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IMAGING OF DOPAMINE TRANSPORTERS WITH IODINE-123-BETA-CIT AND SPECT IN PARKINSONS-DISEASE
Autore:
ASENBAUM S; BRUCKE T; PIRKER W; PODREKA I; ANGELBERGER P; WENGER S; WOBER C; MULLER C; DEECKE L;
Indirizzi:
UNIV ALABAMA,DEPT RADIOL,DIV NUCL MED,619 S 19TH ST BIRMINGHAM AL 35233 UNIV ALABAMA,MED CTR,DEPT NEUROL BIRMINGHAM AL 35294 UNIV ALABAMA,MED CTR,DEPT BIOSTAT & MATH BIRMINGHAM AL 35294
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 1, volume: 38, anno: 1997,
pagine: 1 - 6
SICI:
0161-5505(1997)38:1<1:IODTWI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; I-123 BETA-CIT; PROGRESSIVE SUPRANUCLEAR PALSY; MONOAMINE REUPTAKE SITES; MULTIPLE SYSTEM ATROPHY; HEALTHY-HUMAN SUBJECTS; HUMAN-BRAIN; SUBCELLULAR-LOCALIZATION; SEROTONIN TRANSPORTERS; )H-3>GBR-12935 BINDING;
Keywords:
IODINE-123-BETA-CIT; SPECT; PARKINSONS DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
S. Asenbaum et al., "IMAGING OF DOPAMINE TRANSPORTERS WITH IODINE-123-BETA-CIT AND SPECT IN PARKINSONS-DISEASE", The Journal of nuclear medicine, 38(1), 1997, pp. 1-6

Abstract

The aim of the present study was to demonstrate the degeneration of the dopaminergic nigrostriatal pathway in Parkinson's disease by using the cocaine derivative [I-123]beta-CIT (2-beta-carbomethoxy-3-beta(4-iodophenyl)-tropane or RTI-55) and SPECT and to relate the findings to the severity of the disease (Hoehn and Yahr scale, H/Y) and to clinical data such as motor score and activities of daily living. Methods: Thirteen Volunteers and 47 patients with idiopathic Parkinson's disease (PD) of H/Y Stage I-V (I:n = 16, II:n = 6, III:n = 14, IV:n = 9, V:n =2) were investigated. Acquisitions were performed 2, 4, 16, 20 and 24hr postinjection, ROIs were drawn over the striatum and the cerebellum. Specific beta-CIT binding was defined as striatal minus cerebellar binding. The ratio of specific over nondisplaceable binding (striatum/cerebellum-1) was determined as well as the percent deviation of this ratio from age-expected control values. Results: The time-activity curve of striatal [I-123]beta-CIT binding demonstrated a maximum around 20 hr postinjection in controls and a peak 4 hr postinjection in PD patients. Ratios differed significantly between the two groups. A significant correlation existed between this ratio and clinical measures. Hemiparkinsonian patients revealed significantly diminished [I-123]beta-CIT binding not only contralateral to the clinically affected but also contralateral to the clinically unaffected side. [I-123]beta-CIT binding showed a significant decrease in comparison to age-expected values ranging from 36% in H/Y stage 1 to 71% in H/Y stage V. Conclusion: Thepresent study demonstrates that it is possible to Visualize and quantify the degeneration of dopaminergic nigrostriatal neurons in PD using[I-123]beta-CIT and SPECT with good correlation to clinical parameters.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 22:38:26