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Titolo:
INHIBITION OF SUPEROXIDE PRODUCTION IN HUMAN NEUTROPHILS BY COMBINATIONS OF HEPARIN AND THROMBOLYTIC AGENTS
Autore:
RIESENBERG K; SCHLAEFFER F; KATZ A; LEVY R;
Indirizzi:
SOROKA MED CTR,BEN GURION UNIV NEGEV,FAC HLTH SCI,INTENS CARE UNIT IL-84105 BEER SHEVA ISRAEL SOROKA MED CTR,BEN GURION UNIV NEGEV,FAC HLTH SCI,INTENS CARE UNIT IL-84105 BEER SHEVA ISRAEL SOROKA MED CTR,BEN GURION UNIV NEGEV,FAC HLTH SCI,INFECT DIS LAB IL-84105 BEER SHEVA ISRAEL SOROKA MED CTR,BEN GURION UNIV NEGEV,FAC HLTH SCI,DEPT INTERNAL MED IL-84105 BEER SHEVA ISRAEL
Titolo Testata:
British Heart Journal
fascicolo: 1, volume: 73, anno: 1995,
pagine: 14 - 19
SICI:
0007-0769(1995)73:1<14:IOSPIH>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; NADPH OXIDASE; REPERFUSION INJURY; RESPIRATORY BURST; ACTIVATION; PHAGOCYTES; DISEASE; MECHANISMS; REDUCTION;
Keywords:
SUPEROXIDE PRODUCTION; NEUTROPHILS; HEPARIN; THROMBOLYTIC AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
K. Riesenberg et al., "INHIBITION OF SUPEROXIDE PRODUCTION IN HUMAN NEUTROPHILS BY COMBINATIONS OF HEPARIN AND THROMBOLYTIC AGENTS", British Heart Journal, 73(1), 1995, pp. 14-19

Abstract

Objective-To investigate the effect of heparin and thrombolytic agents on superoxide generation by human neutrophils, as inhibition of superoxide production may have a role in reducing ischaemia and reperfusion injury. Methods-Neutrophil superoxide production stimulated by phorbol myristate acetate (PMA), opsonised zymosan, or formyl methionyl leucyl phenylalanine (FMLP) was measured as the superoxide dismutase inhibitable reduction of acetyl ferricytochrome c by a microtitre plate technique. Results-Heparin, at concentrations of 0.5-500 U/ml, caused a gradual inhibition of superoxide production stimulated by PMA, opsonised zymosan, or FMLP. Tissue plasminogen activator was more potent thanheparin in inhibiting superoxide production induced by opsonised zymosan or FMLP, but it did not affect the activity stimulated by PMA. Streptokinase or urokinase had no effect on superoxide production. When heparin was used in combination with tissue plasminogen activator, streptokinase, or urokinase at their therapeutic concentrations there was a significant inhibition of superoxide generation (70%, 30%, and 25%, respectively). The therapeutic concentrations of tissue plasminogen activator alone caused a reduction of 40% of neutrophil superoxide production. When tissue plasminogen activator and streptokinase were both added to neutrophils, however, a synergistic inhibition of 80% was achieved. Conclusions-The inhibition of super oxide generation by these drug combinations may explain the limited inflammatory response and reduction of reperfusion injury observed in patients receiving thrombolytic treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:02:28