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Titolo:
CELLULAR PHARMACOLOGY AND PROTEIN-BINDING OF PHOSPHOROMONOTHIOATE ANDPHOSPHORODITHIOATE OLIGODEOXYNUCLEOTIDES - A COMPARATIVE-STUDY
Autore:
TONKINSON JL; GUVAKOVA M; KHALED Z; LEE J; YAKUBOV L; MARSHALL WS; CARUTHERS MH; STEIN CA;
Indirizzi:
COLUMBIA UNIV,DEPT MED,630 W 168 ST NEW YORK NY 10032 COLUMBIA UNIV,DEPT MED NEW YORK NY 10032 INST CYTOL & GENET NOVOSIBIRSK 630090 RUSSIA UNIV COLORADO,DEPT CHEM BOULDER CO 80309 NOVOSIBIRSK BIOORGAN CHEM INST NOVOSIBIRSK 630090 RUSSIA
Titolo Testata:
Antisense research and development
fascicolo: 4, volume: 4, anno: 1994,
pagine: 269 - 278
SICI:
1050-5261(1994)4:4<269:CPAPOP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
KINASE-C; PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDES; CULTURED-CELLS; INHIBITION; ACTIVATION; EXPRESSION; AGENT; SITES; LINE; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Tonkinson et al., "CELLULAR PHARMACOLOGY AND PROTEIN-BINDING OF PHOSPHOROMONOTHIOATE ANDPHOSPHORODITHIOATE OLIGODEOXYNUCLEOTIDES - A COMPARATIVE-STUDY", Antisense research and development, 4(4), 1994, pp. 269-278

Abstract

Phosphorodithioate (PS2) oligodeoxynucleotides (oligos) represent a relatively new class of backbone-modified oligo that have potential useas antisense agents. PS2 oligos are isoelectronic with phosphodiester(PO) and phosphoromonothioate (PS) oligos, and are nuclease resistant. However, unlike their PS congeners, PS2 oligos do not contain chiralcenters. Little is known about the manner in which PS2 oligos interact with biological systems. In this study, we compare the cellular pharmacology of PS and PS2 oligos in HL60 cells. Cell surface binding, internalization, and compartmentalization are examined. Furthermore, the ability of PS and PS2 oligos to bind to rsCD4 and bFGF and to inhibit the activity of protein kinase C (PKC) is examined. Although the behavior of PS2 oligos closely parallels that of PS oligos, PS2 oligos appear to interact with some biological systems in a slightly different manner than PS oligos. These results indicate that PS2 oligos may have therapeutic potential other than as antisense agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:41:54