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Titolo:
DELAYED-TYPE HYPERSENSITIVITY RESPONSES IN MICE TRANSPLANTED WITH RATHEPATOCYTES
Autore:
TANABE S; TAURA Y; FURUSAWA S; HIROTA Y; TANAKA M; NAKAICHI M; NAKAMA S;
Indirizzi:
YAMAGUCHI UNIV,FAC AGR,DEPT VET SURG YAMAGUCHI 753 JAPAN NATL INST ANIM HLTH,IMMUNE CYTOL LAB IBARAKI OSAKA 305 JAPAN
Titolo Testata:
Journal of veterinary medical science
fascicolo: 6, volume: 56, anno: 1994,
pagine: 1143 - 1148
SICI:
0916-7250(1994)56:6<1143:DHRIMT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPPRESSOR T-CELLS; HEPATOCELLULAR TRANSPLANTATION; LIVER-CELLS; GUNN RAT; INDUCTION; TOLERANCE; IMMUNITY; AFFERENT; FAILURE; SPLEEN;
Keywords:
DELAYED TYPE HYPERSENSITIVITY; IMMUNOSUPPRESSION; INTRASPLENIC TRANSPLANTATION; XENOGENEIC HEPATOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
S. Tanabe et al., "DELAYED-TYPE HYPERSENSITIVITY RESPONSES IN MICE TRANSPLANTED WITH RATHEPATOCYTES", Journal of veterinary medical science, 56(6), 1994, pp. 1143-1148

Abstract

The delayed type hypersensitivity (DTH) response to xenogeneic hepatocytes (HCs) was investigated in mice received subcutaneous (s.c.), intrasplenic (i.s.), or intravenous (i.v.) transplantation of rat HCs. The DTH response in mice preimmunized i.s. or i.v. with rat HCs (1x10(6)cells) was significantly lower than that in mice preimmunized s.c. with the same doses of rat HCs. Go-transfer of spleen cells from i.s. immunized mice with spleen cells from s.c. immunized mice to naive recipient mice did not suppress the DTH response induced by transfer of spleen cells from s.c. immunized mice. On the other hand, co-transfer of spleen cells from i.v. immunized mice with spleen cells from s.c. immunized mice suppressed the DTH response to rat HCs in recipients. Furthermore, the levels of DTH responses in recipients transferred with spleen cells from mice sensitized i.s. or i.v. with rat HCs, immunized s.c. with rat HCs 6 hr after transfer, and challenged with rat HCs 7 days later was almost similar to those in recipients transferred with spleen cells from s.c. immunized mice. These results suggest that antigen-specific suppression of DTH responses to rat HCs in mice is associated with the presence of suppressive spleen cells induced by i.s. or i.v. immunization with rat HCs.

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Documento generato il 27/11/20 alle ore 13:32:19