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Titolo:
PROLIFERATIVE ACTIVITY OF CYST EPITHELIUM IN HUMAN RENAL CYSTIC DISEASES
Autore:
NADASDY T; LASZIK Z; LAJOIE G; BLICK KE; WHEELER DE; SILVA FG;
Indirizzi:
UNIV OKLAHOMA,HLTH SCI CTR,DEPT PATHOL,BMSB ROOM 451,940 STANTON L YOUNG BLVD OKLAHOMA CITY OK 73104 UNIV OKLAHOMA,HLTH SCI CTR,DEPT PATHOL OKLAHOMA CITY OK 73104 UNIV TEXAS,SW MED CTR,DEPT PATHOL DALLAS TX 00000
Titolo Testata:
Journal of the American Society of Nephrology
fascicolo: 7, volume: 5, anno: 1995,
pagine: 1462 - 1468
SICI:
1046-6673(1995)5:7<1462:PAOCEI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYSTIC KIDNEY-DISEASE; TRANSGENIC MICE; CPK MOUSE; C-MYC; EXPRESSION; CELL; GROWTH; PATHOGENESIS; NEOPLASIA; HISTOGENESIS;
Keywords:
POLYCYSTIC KIDNEY DISEASE; HUMAN; CELL PROLIFERATION; IMMUNOHISTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
T. Nadasdy et al., "PROLIFERATIVE ACTIVITY OF CYST EPITHELIUM IN HUMAN RENAL CYSTIC DISEASES", Journal of the American Society of Nephrology, 5(7), 1995, pp. 1462-1468

Abstract

Increased proliferative activity of the renal tubular epithelium is thought to be a prerequisite for renal cyst formation by many investigators. However, in humans, the exact in vivo proliferation rate of epithelial cells lining these cysts is not known. In this study, which used immunohistochemical methods with an antibody to proliferating cell nuclear antigen (PCNA), the proliferation index (PI) (percentage of PCNA positive cell nuclei among epithelial cells lining the renal cysts) was determined in 10 cases of autosomal dominant polycystic kidney disease (ADPKD), 8 cases of autosomal recessive polycystic kidney disease(ARPKD), and 8 cases of acquired cystic kidney disease (ACKD). Cysts with proximal and distal nephron phenotype and cysts with markedly thickened basement membranes, as well as cysts lined by atrophic (flattened), ''regular'' (cuboidal or cylindrical), and hyperplastic epithelium, were evaluated separately. The overall PI of cyst epithelium (excluding hyperplastic cysts) was 2.58 in ADPKD, was 10.5 in ARPKD, and was3.61 in ACKD. Overall, there were only minor differences in the PI between the various types of cysts. Cysts with hyperplastic epithelium in ACKD (unlike in ADPKD) showed a high PI (9.1). For comparison, the PI of two renal cell carcinomas occurring in two ACKD cases was also determined (13.70 and 8.67%). The PI of tubular epithelium in normal kidneys was only 0.22 to 0.33%, depending on the tubule segment. In contrast, in polycystic kidneys, those noncystic segments of the nephron from which the cysts are thought to originate (distal nephron (specifically collecting duct)) in ARPKD, primarily distal in ADPKD, proximal and distal in ACKD) had PI values similar to those of the cyst epithelium. In summary, these results suggest that (1) increased renal tubular epithelial cell proliferation might precede cyst formation; and/or that (2) increased epithelial cell proliferation by itself may not be sufficient for cyst formation to occur. Hyperplastic renal cyst epithelium may be a precursor of renal epithelial neoplasia in ACKD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:51:58