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Titolo:
INHIBITION OF THE FC RECEPTOR-MEDIATED OXIDATIVE BURST IN MACROPHAGESBY THE YERSINIA-PSEUDOTUBERCULOSIS TYROSINE PHOSPHATASE
Autore:
BLISKA JB; BLACK DS;
Indirizzi:
SUNY STONY BROOK,DEPT MOLEC GENET & MICROBIOL STONY BROOK NY 11794
Titolo Testata:
Infection and immunity
fascicolo: 2, volume: 63, anno: 1995,
pagine: 681 - 685
SICI:
0019-9567(1995)63:2<681:IOTFRO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
OUTER-MEMBRANE PROTEINS; MONOCYTE COMPLEMENT RECEPTORS; PLASMID-CODED PROTEINS; VIRULENCE DETERMINANT; BACTERIAL ATTACHMENT; CHEMI-LUMINESCENCE; MOLECULAR-CLONING; INVASIN PROTEIN; YOP2B PROTEIN; EXPRESSION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
J.B. Bliska e D.S. Black, "INHIBITION OF THE FC RECEPTOR-MEDIATED OXIDATIVE BURST IN MACROPHAGESBY THE YERSINIA-PSEUDOTUBERCULOSIS TYROSINE PHOSPHATASE", Infection and immunity, 63(2), 1995, pp. 681-685

Abstract

Suppression of host-cell-mediated immunity is a hallmark feature of Yersinia pseudotuberculosis infection. To better understand this process, the interaction of Y. pseudotuberculosis with macrophages and the effect of the virulence plasmid-encoded Yersinia tyrosine phosphatase (YopH) on the oxidative burst was analyzed in a chemiluminescence assay. An oxidative burst was generated upon infection of macrophages with a plasmid-cured strain of Y. pseudotuberculosis opsonized with immunoglobulin G antibody. Infection with plasmid-containing Y. pseudatuberculosis inhibited the oxidative burst triggered by secondary infection with opsonized bacteria. The tyrosine phosphatase activity of YopH was necessary for this inhibition. These results indicate that YopH inhibits Fe receptor-mediated signal transduction in macrophages in a globalfashion. In addition, bacterial protein synthesis aas not required far macrophage inhibition, suggesting that YopH export and translocationare controlled at the posttranslational level.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 14:39:04