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Titolo:
POSSIBLE INHIBITION OF HEPATIC-METABOLISM OF QUINIDINE BY ERYTHROMYCIN
Autore:
SPINLER SA; CHENG JWM; KINDWALL KE; CHARLAND SL;
Indirizzi:
PHILADELPHIA COLL PHARM & SCI,600 S 43RD ST PHILADELPHIA PA 19104 UNIV PENN PHILADELPHIA PA 19104
Titolo Testata:
Clinical pharmacology and therapeutics
fascicolo: 1, volume: 57, anno: 1995,
pagine: 89 - 94
SICI:
0009-9236(1995)57:1<89:PIOHOQ>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG QT SYNDROME; PROLONGATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Spinler et al., "POSSIBLE INHIBITION OF HEPATIC-METABOLISM OF QUINIDINE BY ERYTHROMYCIN", Clinical pharmacology and therapeutics, 57(1), 1995, pp. 89-94

Abstract

Objective: To present and analyze a patient case illustrating a possible drug interaction between quinidine and erythromycin. Methods: Thisis a case report of one hospitalized patient, The setting for this analysis was a university hospital. Through a MEDLINE search of all English medical literature (1966 to 1994) documenting possible interactions between quinidine and erythromycin, retrospective patient chart review, and analysis of the relationship between serum quinidine concentrations and significant clinical events, deduce the possibility of a quinidine and erythromycin pharmacokinetic and pharmacodynamic interaction in this particular patient case. Results: This case demonstrated a probable erythromycin-quinidine pharmacokinetic interaction that led toa decrease in quinidine apparent clearance, an increase in quinidine serum concentrations, and a possible quinidine toxicity. Conclusion: Serum quinidine concentrations, electrocardiograms, and other factors that may predispose patients to torsades de pointes, such as hypokalemia and hypomagnesemia, should be monitored closely if quinidine is coadministered with erythromycin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:56:51