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Titolo:
ASSOCIATION BETWEEN PLASMA HOMOCYSTEINE CONCENTRATIONS AND EXTRACRANIAL CAROTID-ARTERY STENOSIS
Autore:
SELHUB J; JACQUES PF; BOSTOM AG; DAGOSTINO RB; WILSON PWF; BELANGER AJ; OLEARY DH; WOLF PA; SCHAEFER EJ; ROSENBERG IH;
Indirizzi:
TUFTS UNIV,USDA,HUMAN NUTR RES CTR AGING,711 WASHINGTON ST BOSTON MA 02111 FRAMINGHAM HEART DIS EPIDEMIOL STUDY FRAMINGHAM MA 00000 BOSTON UNIV,DEPT MATH,STAT & CONSULTING UNIT BOSTON MA 02215 GEISINGER MED CTR,DEPT RADIOL DANVILLE PA 17822 BOSTON UNIV,SCH MED,DEPT NEUROL BOSTON MA 02118 UNIV BOSTON HOSP,EVANS MEM DEPT CLIN RES,PREVENT MED & EPIDEMIOL SECTBOSTON MA 02118 UNIV BOSTON HOSP,DEPT MED BOSTON MA 02118
Titolo Testata:
The New England journal of medicine
fascicolo: 5, volume: 332, anno: 1995,
pagine: 286 - 291
SICI:
0028-4793(1995)332:5<286:ABPHCA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; ATHEROTHROMBOTIC BRAIN INFARCTION; RISK-FACTORS; CARDIOVASCULAR HEALTH; ATHEROSCLEROSIS RISK; VASCULAR-DISEASE; ELDERLY PATIENTS; FOLLOW-UP; ULTRASOUND; FOLATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
J. Selhub et al., "ASSOCIATION BETWEEN PLASMA HOMOCYSTEINE CONCENTRATIONS AND EXTRACRANIAL CAROTID-ARTERY STENOSIS", The New England journal of medicine, 332(5), 1995, pp. 286-291

Abstract

Background. Epidemiologic studies have identified hyperhomocysteinemia as a possible risk factor for atherosclerosis. We determined the risk of carotid-artery atherosclerosis in relation to both plasma homocysteine concentrations and nutritional determinants of hyperhomocysteinemia. Methods. We performed a cross-sectional study of 1041 elderly subjects (418 men and 623 women; age range, 67 to 96 years) from the Framingham Heart Study. We examined the relation between the maximal degree of stenosis of the extracranial carotid arteries (as assessed by ultrasonography) and plasma homocysteine concentrations, as well as plasma concentrations and intakes of vitamins involved in homocysteine metabolism, including folate, vitamin B-12, and vitamin B-6. The subjects were classified into two categories according to the findings in the more diseased of the two carotid vessels: stenosis of 0 to 24 percent and stenosis of 25 to 100 percent. Results. The prevalence of carotid stenosis of less than or equal to 25 percent was 43 percent in the men and 34 percent in the women. The odds ratio for stenosis of greater than or equal to 25 percent was 2.0 (95 percent confidence interval, 1.4to 2.9) for subjects with the highest plasma homocysteine concentrations (greater than or equal to 14.4 mu mol per liter) as compared with those with the lowest concentrations (less than or equal to 9.1 mu molper liter), after adjustment for sex, age, plasma high-density lipoprotein cholesterol concentration, systolic blood pressure, and smoking status (P<0.001 for trend). Plasma concentrations of folate and pyridoxal-5'-phosphate (the coenzyme form of vitamin B-6) and the level of folate intake were inversely associated with carotid-artery stenosis after adjustment for age, sex, and other risk factors.Conclusions. High plasma homocysteine concentrations and low concentrations of folate and vitamin B,, through their role in homocysteine metabolism, are associated with an increased risk of extracranial carotid-artery stenosis in the elderly.

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Documento generato il 03/12/20 alle ore 05:42:56