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Titolo:
GROWTH-HORMONE RESPONSE TO CLONIDINE IN THE NERVOUS POINTER DOG-MODELOF ANXIETY
Autore:
UHDE TW; MALLOY LC; BENSON BB;
Indirizzi:
WAYNE STATE UNIV,UNIV HLTH CTR,DEPT PSYCHIAT & BEHAV NEUROSCI,PSYCHIAT 9B21,4201 ST ANTOINE DETROIT MI 48201 NIMH,INTRAMURAL RES PROGRAM,BIOL PSYCHIAT BRANCH,ANXIETY & AFFECT DISORDERS SECT BETHESDA MD 20892
Titolo Testata:
Anxiety
fascicolo: 2, volume: 1, anno: 1994,
pagine: 45 - 49
SICI:
1070-9797(1994)1:2<45:GRTCIT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-ADRENERGIC REGULATION; PANIC DISORDER PATIENTS; NORADRENERGIC FUNCTION; BODY SIZE; I LEVELS; SECRETION; PLASMA; SENSITIVITY; PROLACTIN; RELEASE;
Keywords:
ANXIETY; FEAR; GROWTH FACTORS; GROWTH HORMONE; CLONIDINE; DOGS; CANINE; NORADRENERGIC; ANIMAL MODELS; ALPHA-ADRENERGIC RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
T.W. Uhde et al., "GROWTH-HORMONE RESPONSE TO CLONIDINE IN THE NERVOUS POINTER DOG-MODELOF ANXIETY", Anxiety, 1(2), 1994, pp. 45-49

Abstract

Blunted growth hormone responses to clonidine have been reported in most studies of humans with panic disorder but have been an inconsistent finding in the study of other anxiety syndromes. The growth hormone response to oral clonidine (100 mu g/kg) was investigated in the adultnervous pointer dog, it genetic animal model of anxiety. Compared with placebo, clonidine produced significant increases in plasma levels of growth hormone; however; there were no differences in the growth hormone (GH) responses to clonidine in the nervous compared with the normal pointer dogs. Findings in this animal model are discussed within the context of noradrenergic-hypothalamic-GH dysfunction reported in some but not all types of anxiety disorders in humans. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:16:15