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Titolo:
THE CELL-DEATH INHIBITOR BCL-2 AND ITS HOMOLOGS INFLUENCE CONTROL OF CELL-CYCLE ENTRY
Autore:
OREILLY LA; HUANG DCS; STRASSER A;
Indirizzi:
ROYAL MELBOURNE HOSP,WALTER & ELIZA HALL INST MED RES PARKVILLE VIC 3050 AUSTRALIA ROYAL MELBOURNE HOSP,WALTER & ELIZA HALL INST MED RES PARKVILLE VIC 3050 AUSTRALIA
Titolo Testata:
EMBO journal
fascicolo: 24, volume: 15, anno: 1996,
pagine: 6979 - 6990
SICI:
0261-4189(1996)15:24<6979:TCIBAI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TRANSGENIC MICE; ICE-LIKE PROTEASES; C-MYC; CAENORHABDITIS-ELEGANS; NEGATIVE SELECTION; LYMPHOID-CELLS; T-CELLS; MITOCHONDRIAL-MEMBRANE; POSITIVE SELECTION; INDUCE APOPTOSIS;
Keywords:
APOPTOSIS; BCL-2; BCL-X(L); CELL CYCLE CONTROL; E1B19KD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
L.A. Oreilly et al., "THE CELL-DEATH INHIBITOR BCL-2 AND ITS HOMOLOGS INFLUENCE CONTROL OF CELL-CYCLE ENTRY", EMBO journal, 15(24), 1996, pp. 6979-6990

Abstract

The effect of the cell death inhibitor Bcl-2 and its homologues on cell cycle regulation was explored in lymphocytes and cell lines. Expression of a bcl-2 transgene reduced proliferation of thymocytes and delayed cell cycle entry of mitogen-stimulated B and T lymphocytes. Overexpression of Bcl-2, Bcl-x(L) or adenovirus E1B19kD substantially delayed serum stimulation-induced S phase entry of quiescent NIH 3T3 fibroblasts. Bcl-2-mediated cell survival and growth inhibition are both antagonized by Bar. Bcl-2, Bcl-x(L) and E1B19kD, but not Bcl-2 mutants that are defective in blocking apoptosis, suppress growth of colon carcinoma cells. This evidence that regulation of cell survival is coupled to control of cell growth has implications for normal cell turnover andtumorigenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:16:12