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Titolo:
GIANT PROTEIN-KINASES - DOMAIN INTERACTIONS AND STRUCTURAL BASIS OF AUTOREGULATION
Autore:
KOBE B; HEIERHORST J; FEIL SC; PARKER MW; BENIAN GM; WEISS KR; KEMP BE;
Indirizzi:
ST VINCENTS INST MED RES,41 VICTORIA PARADE FITZROY VIC 3065 AUSTRALIA ST VINCENTS INST MED RES FITZROY VIC 3065 AUSTRALIA MT SINAI SCH MED,DEPT PHYSIOL & BIOPHYS NEW YORK NY 10029 EMORY UNIV,DEPT PATHOL ATLANTA GA 30322
Titolo Testata:
EMBO journal
fascicolo: 24, volume: 15, anno: 1996,
pagine: 6810 - 6821
SICI:
0261-4189(1996)15:24<6810:GP-DIA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIGHT-CHAIN KINASE; CAENORHABDITIS-ELEGANS; CRYSTAL-STRUCTURE; SMOOTH-MUSCLE; MOLECULAR REPLACEMENT; MOLLUSCAN TWITCHIN; CATALYTIC SUBUNIT; PEPTIDE COMPLEX; MYOSIN; CALMODULIN;
Keywords:
CRYSTAL STRUCTURE; IMMUNOGLOBULIN; INTRASTERIC REGULATION; PROTEIN KINASE; TWITCHIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
74
Recensione:
Indirizzi per estratti:
Citazione:
B. Kobe et al., "GIANT PROTEIN-KINASES - DOMAIN INTERACTIONS AND STRUCTURAL BASIS OF AUTOREGULATION", EMBO journal, 15(24), 1996, pp. 6810-6821

Abstract

The myosin-associated giant protein kinases twitchin and titin are composed predominantly of fibronectin- and immunoglobulin-like modules, We report the crystal structures of two autoinhibited twitchin kinase fragments, one from Aplysia and a larger fragment from Caenorhabditis elegans containing an additional C-terminal immunoglobulin-like domain, The structure of the longer fragment shoes that the immunoglobulin domain contacts the protein kinase domain on the opposite side from thecatalytic cleft, laterally exposing potential myosin binding residues, Together, the structures reveal the cooperative interactions betweenthe autoregulatory region and the residues from the catalytic domain involved in protein substrate binding, ATP binding, catalysis and the activation loop, and explain the differences between the observed autoinhibitory mechanism and the one found in the structure of calmodulin-dependent kinase I.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 03:35:52