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Titolo:
AIRWAY MUCUS AND EPITHELIAL FUNCTION IN A CANINE MODEL OF SINGLE-LUNGAUTOTRANSPLANTATION
Autore:
TOMKIEWICZ RP; APP EM; SHENNIB H; RAMIREZ O; NGUYEN D; KING M;
Indirizzi:
UNIV ALBERTA,PULM RES GRP,173 HERITAGE MED RES CTR EDMONTON AB T6G 2S2 CANADA UNIV ALBERTA,PULM RES GRP EDMONTON AB T6G 2S2 CANADA MCGILL UNIV,DEPT SURG MONTREAL PQ H3A 2T5 CANADA GSF RES CTR ENVIRONM & HLTH MUNICH GERMANY
Titolo Testata:
Chest
fascicolo: 1, volume: 107, anno: 1995,
pagine: 261 - 265
SICI:
0012-3692(1995)107:1<261:AMAEFI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CILIARY BEAT FREQUENCY; MUCOCILIARY FUNCTION; HEART-LUNG; POTENTIAL DIFFERENCE; TRANSPLANTATION; TRANSPORT; CLEARANCE; RHEOLOGY; INVIVO;
Keywords:
LUNG CLEARANCE; LUNG TRANSPLANTATION; MUCUS RHEOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
R.P. Tomkiewicz et al., "AIRWAY MUCUS AND EPITHELIAL FUNCTION IN A CANINE MODEL OF SINGLE-LUNGAUTOTRANSPLANTATION", Chest, 107(1), 1995, pp. 261-265

Abstract

Impaired mucociliary function following lung transplantation has beenreported in several human and animal studies. This could be a result of altered ciliary function or mucus properties or both. We assessed airway epithelial function by means of transepithelial potential difference (PD) measurements and physical analysis of mucus. Six mongrel dogs underwent single lung autologous transplantation. Measurements were performed preoperatively and 1, 2, 4, and 10 months postoperatively. At 1 and 2 months postoperatively, there was a significant fall in PD for the transplanted, left mainstem bronchus only (-13.5+/-1.7 mV at 1 month and -14.6+/-1.7 mV at 2 month postoperatively vs -18.6+/-2.3 mV preoperatively, baseline; p<0.001 for both). The PD values in the small airways, right mainstem bronchus, and the trachea remained unchanged. At 2 months postoperation, the mucus collection rate on the left side was increased (p=0.03), while the mucus viscoelasticity was decreased (p=0.04). By 4 months postoperation, all epithelial parameters had returned to baseline, and there was no difference in radioaerosol clearance between the two lungs. The PD decrease and alterations in secretion rate and viscoelasticity reflect disturbed epithelial functional integrity at the site of anastomosis still present at 2 months postoperation. Recovery of bronchial epithelial function and clearance in canine studies of lung autotransplantation after healing of the anastomosisarea suggest that persistent impairment of lung clearance observed insome long-term human lung transplantation survivors may be due to other mechanisms such as impaired healing or epithelial function or both,during immunosuppressive therapy. Mucociliary function in the anastomosis area is compromised until complete healing ensues; we speculate that chest physiotherapy may aid in overcoming this obstacle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 04:18:07