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Titolo:
CYTOSTATIC GENE-THERAPY FOR VASCULAR PROLIFERATIVE DISORDERS WITH A CONSTITUTIVELY ACTIVE FORM OF THE RETINOBLASTOMA GENE-PRODUCT
Autore:
CHANG MW; BARR E; SELTZER J; JIANG YQ; NABEL GJ; NABEL EG; PARMACEK MS; LEIDEN JM;
Indirizzi:
UNIV CHICAGO,DEPT MED CHICAGO IL 60637 UNIV CHICAGO,DEPT MED CHICAGO IL 60637 UNIV CHICAGO,DEPT PATHOL CHICAGO IL 60637 UNIV MICHIGAN,MED CTR,DEPT MED ANN ARBOR MI 48109 UNIV MICHIGAN,MED CTR,DEPT BIOL CHEM ANN ARBOR MI 48109 UNIV MICHIGAN,MED CTR,HOWARD HUGHES MED INST ANN ARBOR MI 48109
Titolo Testata:
Science
fascicolo: 5197, volume: 267, anno: 1995,
pagine: 518 - 522
SICI:
0036-8075(1995)267:5197<518:CGFVPD>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE CELL-PROLIFERATION; TRANSCRIPTION FACTOR; CYCLE; ATHEROSCLEROSIS; RESTENOSIS; PROTEIN; P53; OLIGONUCLEOTIDES; BINDING; INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
M.W. Chang et al., "CYTOSTATIC GENE-THERAPY FOR VASCULAR PROLIFERATIVE DISORDERS WITH A CONSTITUTIVELY ACTIVE FORM OF THE RETINOBLASTOMA GENE-PRODUCT", Science, 267(5197), 1995, pp. 518-522

Abstract

Vascular smooth muscle cell (SMC) proliferation in response to injuryis an important etiologic factor in vascular proliferative disorders such as atherosclerosis and restenosis after balloon angioplasty. The retinoblastoma gene product (Rb) is present in the unphosphorylated and active form in quiescent primary arterial SMCs, but is rapidly inactivated by phosphorylation in response to growth factor stimulation in vitro, A replication-defective adenovirus encoding a nonphosphorylatable, constitutively active form of Rb was constructed. Infection of cultured primary rat aortic SMCs with this virus inhibited growth factor-stimulated cell proliferation in vitro. Localized arterial infection with the virus at the time of balloon angioplasty significantly reducedSMC proliferation and neointima formation in both the rat carotid andporcine femoral artery models of restenosis, These results demonstrate the role of Rb in regulating vascular SMC proliferation and suggest a gene therapy approach for vascular proliferative disorders associated with arterial injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:18:19