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Titolo:
ZETA-PHOSPHORYLATION WITHOUT ZAP-70 ACTIVATION-INDUCED BY TCR ANTAGONISTS OR PARTIAL AGONISTS
Autore:
MADRENAS J; WANGE RL; WANG JL; ISAKOV N; SAMELSON LE; GERMAIN RN;
Indirizzi:
NIAID,IMMUNOL LAB,LYMPHOCYTE BIOL SECT,BLDG 10 BETHESDA MD 20892 NICHHD,CELL BIOL & METAB BRANCH BETHESDA MD 20892
Titolo Testata:
Science
fascicolo: 5197, volume: 267, anno: 1995,
pagine: 515 - 518
SICI:
0036-8075(1995)267:5197<515:ZWZABT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL-RECEPTOR; ANTIGEN-PRESENTING CELLS; TYROSINE PHOSPHORYLATION; CYTOCHROME-C; COMPLEX; CHAIN; LIGAND; COMPONENTS; ANALOG; KINASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
J. Madrenas et al., "ZETA-PHOSPHORYLATION WITHOUT ZAP-70 ACTIVATION-INDUCED BY TCR ANTAGONISTS OR PARTIAL AGONISTS", Science, 267(5197), 1995, pp. 515-518

Abstract

Small changes in the peptide-major histocompatibility complex (MHC) molecule ligands recognized by antigen-specific T cell receptors (TCRs)can convert fully activating complexes into partially activating or even inhibitory ones, This study examined early TCR-dependent signals induced by such partial agonists or antagonists, In contrast to typicalagonist ligands, both an antagonist and several partial agonists stimulated a distinct pattern of zeta chain phosphorylation and failed to activate associated ZAP-70 kinase, These results identify a specific step in the early tyrosine phosphorylation cascade that is altered after TCR engagement with modified peptide-MHC molecule complexes, This finding may explain the different biological responses to TCR occupancy by these variant ligands.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:11:16