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Titolo:
EARLY EXPRESSION OF CHROMOGRANIN-A AND TYROSINE-HYDROXYLASE DURING PRENATAL DEVELOPMENT OF THE BOVINE ADRENAL-GLAND
Autore:
TOTZAUER I; AMSELGRUBER W; SINOWATZ F; GRATZL M;
Indirizzi:
UNIV MUNICH,INST TIERANAT 2,VETERINARSTR 13 D-80539 MUNICH GERMANY UNIV ULM,ANAT & ZELLBIOL ABT D-89069 ULM GERMANY
Titolo Testata:
Anatomy and embryology
fascicolo: 2, volume: 191, anno: 1995,
pagine: 139 - 143
SICI:
0340-2061(1995)191:2<139:EEOCAT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMAFFIN; PROTEINS; TISSUE; CELLS; ENDOCRINE; CA-2+;
Keywords:
CHROMOGRANIN A; TYROSINE HYDROXYLASE; DEVELOPMENT; ADRENAL GLAND; BOVINE FETUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
I. Totzauer et al., "EARLY EXPRESSION OF CHROMOGRANIN-A AND TYROSINE-HYDROXYLASE DURING PRENATAL DEVELOPMENT OF THE BOVINE ADRENAL-GLAND", Anatomy and embryology, 191(2), 1995, pp. 139-143

Abstract

The present study was undertaken to define the temporal pattern and distribution of cells positive for chromogranin A (CgA) and tyrosine hydroxylase (TH) in various developmental stages of fetal bovine adrenalgland. CgA is an acidic protein, co-stored and co-released with amines and a variety of peptide hormones and neurotransmitters in dense core vesicles of neural and endocrine cells and can be used as a marker for these cells and their malignant counterparts. TH is the rate-limiting enzyme in catecholamine biosynthesis and reflects noradrenergic differentiation. The expression of CgA and TH was examined by immunohistochemistry. CgA immunoreactivity appears first in 35-day-old bovine fetuses. By the end of the second month, CgA-labelled cells are scatteredthroughout the entire primordium of the adrenal gland, and at a fetalage of 85-91 days most of these cells concentrate in the developing adrenal medulla. From this stage onwards, immunoreactive cells of the marginal zone of the medulla exhibit significantly stronger CgA immunoreaction than the central area. TH immunoreactivity appeared in the adrenal primordium for the first time at the end of the second month of gestation. The distribution pattern of TH-positive cells was similar tothat described for CgA, and no significant differences in topographical arrangement between TH- and CgA-positive cells can be detected. Theresults show that bovine adrenal chromaffin cells express CgA alreadyduring their earliest stages of development and prior to TH. The stronger immunoreaction of marginal adrenal medullary cells suggests an adrenalcortical effect of glucocorticoids on the expression of CgA.

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Documento generato il 04/12/20 alle ore 20:46:51