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Titolo:
IMMUNOLOGICAL RESPONSES TO SOLUBLE EXOANTIGENS OF PLASMODIUM-FALCIPARUM IN GABONESE CHILDREN EXPOSED TO CONTINUOUS INTENSE INFECTION
Autore:
LUTY AJF; MAYOMBO J; LEKOULOU F; MSHANA R;
Indirizzi:
CTR INT RECH MED FRANCEVILLE,IMMUNOPARASITOL UNIT FRANCEVILLE GABON INT INST SCI RES DEV AFRICA ABIDJAN COTE IVOIRE
Titolo Testata:
The American journal of tropical medicine and hygiene
fascicolo: 6, volume: 51, anno: 1994,
pagine: 720 - 729
SICI:
0002-9637(1994)51:6<720:IRTSEO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; INVITRO LYMPHOPROLIFERATIVE RESPONSES; HUMORAL IMMUNE-RESPONSE; MALARIA EXOANTIGENS; FACTOR INDUCTION; CLINICAL MALARIA; MESOENDEMIC AREA; HOLOENDEMIC AREA; GAMBIAN CHILDREN; MURINE MALARIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
A.J.F. Luty et al., "IMMUNOLOGICAL RESPONSES TO SOLUBLE EXOANTIGENS OF PLASMODIUM-FALCIPARUM IN GABONESE CHILDREN EXPOSED TO CONTINUOUS INTENSE INFECTION", The American journal of tropical medicine and hygiene, 51(6), 1994, pp. 720-729

Abstract

The development of antidisease immunity in children infected with Plas modium falciparum is thought to be related to their immunologic responses to certain soluble parasite-derived exoantigens. We have assessed both cellular and humoral responses to these antigens in a cross-sectional study of a cohort of Gabonese schoolchildren who live in an area where malaria is holoendemic and perenially transmitted, in an attempt to identify immunologic markers of this early developing protectiveimmunity. Concurrent parasitemia was found to have a significant influence on lymphoproliferative and antibody responses to the exoantigens. Individuals with higher levels of parasitemia had significantly lower proliferative and IgG isotype responses. Higher concentrations of specific IgG1 and IgG3, in particular, were associated with lower or no parasitemia, suggesting a possible protective role for these isotypes,whereas the level of IgM antibodies showed a trend towards higher concentrations in those with parasitemia, perhaps indicative of an exoantigen-induced T cell-independent response. Cytokine responses were unaffected by either the presence or the intensity of parasitemia and weredissociated from both proliferative and antibody responses to the exoantigens. However, the mitogen-stimulated production of tumor-necrosisfactor-alpha (TNF-alpha) and interleukin-6 (IL)-6 was positively correlated with the corresponding lymphoproliferative responses. At the individual level, mitogen-stimulated TNF-alpha, interferon-gamma, IL-2, and IL-6 responses were positively correlated, as were mitogen- and exoantigen-induced TNF-alpha. The results are discussed in the light of current knowledge of immune responses to the exoantigens and the development of protective immunity to P. falciparum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:01:23