Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECTS OF NIFEDIPINE ON VASCULAR WATERFALL AND ARTERIAL RESISTANCE IN CANINE HINDLIMB
Autore:
SHRIER I; MAGDER S;
Indirizzi:
SIR MORTIMER B DAVIS JEWISH HOSP,HERZL FAMILY PRACTICE CTR,RM E-0010,5757 LEGARE MONTREAL PQ H3T 1Z6 CANADA MCGILL UNIV,MEAKINS CHRISTIE LABS MONTREAL PQ H3T 1Z6 CANADA ROYAL VICTORIA HOSP,DIV CRIT CARE MONTREAL PQ H3T 1Z6 CANADA
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 1, volume: 37, anno: 1995,
pagine: 371 - 376
SICI:
0363-6135(1995)37:1<371:EONOVW>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CRITICAL CLOSING PRESSURE; ZERO-FLOW PRESSURE; SKELETAL-MUSCLE; MECHANICS; TONE;
Keywords:
PRESSURE-FLOW RELATION; CRITICAL PRESSURE; VENOUS RESISTANCE; MYOGENIC RESPONSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
I. Shrier e S. Magder, "EFFECTS OF NIFEDIPINE ON VASCULAR WATERFALL AND ARTERIAL RESISTANCE IN CANINE HINDLIMB", American journal of physiology. Heart and circulatory physiology, 37(1), 1995, pp. 371-376

Abstract

Pressure-flow relations in the canine hindlimb can be well explained by a vascular waterfall at the arteriolar level. Under these conditions, P-art = P-crit + Q.R(art), where P-art is the arterial pressure, P-crit is the waterfall pressure, Q is regional flow, and R(art) is the arterial resistance of the vessels upstream from the waterfall. To determine whether calcium channels in vascular smooth muscle affect P-crit in addition to R(art), we pump perfused canine hindlimbs and measured both variables over a range of perfusion pressures (P-per) before and during the infusion of the calcium channel blocker nifedipine. Nifedipine significantly decreased P-crit and R(art) at each P-per. Increasing P-per under control conditions from 50 to 150 mmHg significantly increased P-crit from 24.2 +/- 1.5 to 42.5 +/- 2.2 mmHg. During nifedipine infusion, increasing P-per from 25 to 100 mmHg also increased P-crit, from 14.5 +/-: 1.5 to 20.2 +/- 1.9 mmHg, but the rate of increase was less. In contrast to the rise in P-crit with increasing P-per, R(art) significantly decreased from 10.7 +/- 1.1 to 8.1 +/- 1.2 mmHg.min.100 g.ml(-1) before nifedipine infusion, and from 5.7 +/- 0.4 to 2.2 +/- 0.1 mmHg min 100 g.ml(-1) during nifedipine infusion. Venous resistance (R(ven)) significantly decreased with increases in P-per and during nifedipine infusion. The regional elastic recoil pressure (Pa a measure of small venular pressure) increased with both an increase in P-per and nifedipine. These results suggest that nifedipine decreases P-crit, R(art), and R(ven) and that at constant P-per nifedipine increases P-el.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:49:56