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Titolo:
HYPOXIC INTRACELLULAR CA2-ARTERIES - EVIDENCE FOR PKC-INDEPENDENT CA2+ SENSITIZATION( IN PULMONARY)
Autore:
ROBERTSON TP; AARONSON PI; WARD JPT;
Indirizzi:
UNITED MED & DENT SCH,ST THOMAS HOSP,DEPT MED,RESP RES LAB LONDON SE17EH ENGLAND UNITED MED & DENT SCH,ST THOMAS HOSP,DEPT MED,RESP RES LAB LONDON SE17EH ENGLAND
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 1, volume: 37, anno: 1995,
pagine: 301 - 307
SICI:
0363-6135(1995)37:1<301:HIC-EF>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; SMOOTH-MUSCLE CELLS; INCREASES CYTOSOLIC CALCIUM; RAT PULMONARY; SELECTIVE INHIBITORS; CONTRACTION; VASOCONSTRICTION; ENDOTHELIUM; MODULATION; RESPONSES;
Keywords:
PULMONARY VASCULATURE; HYPOXIA; VASCULAR SMOOTH MUSCLE; ENDOTHELIUM-DERIVED CONSTRICTING FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
T.P. Robertson et al., "HYPOXIC INTRACELLULAR CA2-ARTERIES - EVIDENCE FOR PKC-INDEPENDENT CA2+ SENSITIZATION( IN PULMONARY)", American journal of physiology. Heart and circulatory physiology, 37(1), 1995, pp. 301-307

Abstract

The effect of hypoxia on intracellular Ca2+ ([Ca2+](i)) and tension in small intrapulmonary arteries (IPA) of the rat was examined using the Ca2+ fluorophore fura 2. Induction of hypoxia in IPA preconstricted with 3 mu M prostaglandin F-2 alpha (PGF(2 alpha)) resulted in a biphasic contractile response, the first phase of which was associated witha transient rise in [Ca2+](i). No additional rise in [Ca2+](i) was observed during the more slowly developing second phase constriction. Upon reoxygenation [Ca2+](i) and tension returned to prehypoxic levels. Ro-31-8220 [a specific protein kinase C (PKC) inhibitor] reduced the first phase in IPA preconstricted with PGF(2 alpha) or 20 mM KCl, but had no effect on the second phase constriction in either of these groups. These results demonstrate that the first phase of the hypoxic constriction is associated with a transient rise in [Ca2+](i), via either Ca2+ influx and/or release, and may have a PKC-dependent component, whereas the second phase involves a PKC-independent sensitization of the contractile machinery to Ca2+.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 05:22:21