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Titolo:
A ROLE FOR CNS ALPHA-2-ADRENERGIC RECEPTORS IN OPIATE-INDUCED MUSCLE RIGIDITY IN THE RAT
Autore:
WEINGER MB; CHEN DY; LIN T; LAU C; KOOB GF; SMITH NT;
Indirizzi:
VET AFFAIRS MED CTR,ANESTHESIA RES SERV,3350 LA JOLLA VILLAGE DR SAN DIEGO CA 92161 UNIV CALIF SAN DIEGO,SCH MED,DEPT ANESTHESIOL LA JOLLA CA 92093 SCRIPPS CLIN & RES INST,DEPT NEUROPHARMACOL LA JOLLA CA 92037
Titolo Testata:
Brain research
fascicolo: 1, volume: 669, anno: 1995,
pagine: 10 - 18
SICI:
0006-8993(1995)669:1<10:ARFCAR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED MUSCULAR RIGIDITY; COERULOSPINAL NORADRENERGIC PATHWAY; MORPHINE-INDUCED CATALEPSY; NUCLEUS RAPHE PONTIS; LOCUS COERULEUS; ALFENTANIL; INVOLVEMENT; BRAIN; SITES; MECHANISMS;
Keywords:
MUSCLE RIGIDITY; DEXMEDETOMIDINE; METHYLNALOXONIUM; KETANSERIN; ALPHA ADRENERGIC RECEPTOR; ALFENTANIL; ELECTROMYOGRAPHY; ST91;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
M.B. Weinger et al., "A ROLE FOR CNS ALPHA-2-ADRENERGIC RECEPTORS IN OPIATE-INDUCED MUSCLE RIGIDITY IN THE RAT", Brain research, 669(1), 1995, pp. 10-18

Abstract

A number of potential neurochemical mediators of opiate-induced muscle rigidity have been proposed based on the results of systemic drug studies and on knowledge of the brain sites implicated in opiate rigidity. The effects of i.c.v, pretreatment with selected opioidergic, alphaadrenergic and serotonergic drugs on muscle rigidity induced with systemic injection of the potent opiate agonist alfentanil (ALF) were investigated in spontaneously ventilating rats. The opiate antagonist methylnaloxonium (MN; 0.2-14 nmol), alpha-2 adrenergic agonists dexmedetomidine (DEX; 0.4-42 nmol) or 2-(2,6-diethylphenylamino)-2-imidazoline hydrochloride (ST91; 4-400 nmol), alpha-1 adrenergic antagonist prazosin (PRZ; 7-70 nmol) or serotonergic antagonist ketanserin (KET; 18-550nmol) were injected i.c.v. (10 mu l) and ALF (500 mu g/kg s.c.) was administered 10 min later. S.c. electrodes were used to record gastrocnemius electromyographic activity. Both MN and DEX dose-dependently andpotently antagonized ALF-induced rigidity. ST91 produced shorter-lived, less profound, antagonism of ALF rigidity. PRZ, at the highest dosetested, produced a delayed and modest reduction in ALF rigidity. A large, non-selective, dose of KET incompletely attenuated ALF rigidity. These results lend support to the hypothesis that central opioid and alpha-2 adrenergic receptors mediate opiate-induced muscle rigidity in the rat.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:50:02