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Titolo:
ARTERIAL AND CARDIOPULMONARY BAROREFLEX CONTROL OF RENAL NERVE ACTIVITY IN CIRRHOSIS
Autore:
RODRIGUEZMARTINEZ M; SAWIN LL; DIBONA GF;
Indirizzi:
UNIV IOWA,COLL MED,DEPT INTERNAL MED IOWA CITY IA 52242 UNIV IOWA,COLL MED,DEPT INTERNAL MED IOWA CITY IA 52242 VET AFFAIRS MED CTR IOWA CITY IA 52242
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 1, volume: 37, anno: 1995,
pagine: 117 - 129
SICI:
0363-6119(1995)37:1<117:AACBCO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-FAILURE; REFLEX; MODEL;
Keywords:
RENAL NERVE ACTIVITY; HEPATIC CIRRHOSIS; ARTERIAL BARORECEPTORS; CARDIAC BARORECEPTORS; SALINE VOLUME EXPANSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
M. Rodriguezmartinez et al., "ARTERIAL AND CARDIOPULMONARY BAROREFLEX CONTROL OF RENAL NERVE ACTIVITY IN CIRRHOSIS", American journal of physiology. Regulatory, integrative and comparative physiology, 37(1), 1995, pp. 117-129

Abstract

Cirrhotic rats (common bile duct ligation; CBDL) have increased efferent renal sympathetic nerve activity (ERSNA), which contributes significantly to the observed renal sodium and water retention and edema formation. Basal ERSNA is increased and fails to suppress normally duringintravenous isotonic saline volume expansion. Arterial and cardiopulmonary baroreflex control of ERSNA in CBDL and control (CTR) rats was examined. CBDL rats exhibited hyperdynamic circulation with increased cardiac index and decreased total peripheral resistance index and arterial pressure compared with CTR rats. Increases in left ventricular end-diastolic pressure (LVEDP) produced by volume expansion increased cardiac index normally in CBDL rats. The maximal gain of aortic baroreflex control of ERSNA was similar in CBDL and CTR rats. In CBDL rats, during decreased arterial pressure, there was a decreased range of the central component, which accounted for the decreased range of the overall aortic baroreflex, with the range of the afferent component being normal. For cardiopulmonary baroreflex control of ERSNA, the LVEDP threshold was increased and the gain was decreased in CBDL compared with CTR rats; this was due to an increased LVEDP threshold and a diminished gain of the afferent component while the central portion of the reflexwas normal. These abnormalities in the cardiopulmonary baroreflex account for the attenuated decrease in ERSNA in CBDL compared with CTR rats during volume expansion. In CBDL rats, attenuation of cardiopulmonary baroreflex control of ERSNA contributes to both the increased basalERSNA and its failure to normally suppress during volume expansion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 13:26:38