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Titolo:
A NEURAL MODEL OF MEMORY IMPAIRMENT IN DIFFUSE CEREBRAL ATROPHY
Autore:
RUPPIN E; REGGIA JA;
Indirizzi:
UNIV MARYLAND,DEPT COMP SCI,AV WILLIAMS BLDG COLLEGE PK MD 20742
Titolo Testata:
British Journal of Psychiatry
, volume: 166, anno: 1995,
pagine: 19 - 28
SICI:
0007-1250(1995)166:<19:ANMOMI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMER-TYPE DEMENTIA; AUTOBIOGRAPHICAL MEMORY; RETROGRADE-AMNESIA; ASSOCIATIVE MEMORY; TEMPORAL CORTEX; DISEASE; NETWORKS; KORSAKOFF; REMOTE; LEVEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
E. Ruppin e J.A. Reggia, "A NEURAL MODEL OF MEMORY IMPAIRMENT IN DIFFUSE CEREBRAL ATROPHY", British Journal of Psychiatry, 166, 1995, pp. 19-28

Abstract

Background. Computer-supported neural network models have been subjected to diffuse. progressive deletion of synapses/neurons, to show thatmodelling cerebral neuropathological changes can predict the pattern of memory degradation in diffuse degenerative processes such as Alzheimer's disease. However, it has been suggested that neural models cannot account for more detailed aspects of memory impairment, such as the relative sparing of remote versus recent memories. Method. The latter claim is examined from a computational perspective, using a neural associative memory model. Results. The neural network model not only demonstrates progressive memory deterioration as diffuse network damage occurs, but also exhibits differential sparing of remote versus recent memories. Conclusions. Our results show that neural models can account for a large variety of experimental phenomena characterising memory degradation in Alzheimer's patients. Specific testable predictions are generated concerning the relation between the neuroanatomical findings and the clinical manifestations of Alzheimer's disease.

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Documento generato il 02/04/20 alle ore 00:11:04