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Titolo:
A COMPARATIVE-STUDY OF SERUM ALPHA-BETA-A IMMUNOREACTIVE INHIBIN AND TUMOR-ASSOCIATED ANTIGENS CA125 AND CEA IN OVARIAN-CANCER
Autore:
PHOCAS I; SARANDAKOU A; SIKIOTIS K; RIZOS D; KALAMBOKIS D; ZOURLAS PA;
Indirizzi:
UNIV ATHENS,ARETEION HOSP,HORMONAL LAB,DEPT OBSTET & GYNECOL 2,76 VASSOPHIAS AVE ATHENS 11528 GREECE
Titolo Testata:
Anticancer research
fascicolo: 6B, volume: 16, anno: 1996,
pagine: 3827 - 3831
SICI:
0250-7005(1996)16:6B<3827:ACOSAI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTMENOPAUSAL WOMEN; MONOCLONAL-ANTIBODY; CARCINOEMBRYONIC ANTIGEN; CA-125 LEVELS; CARCINOMA;
Keywords:
ALPHA-BETA-A IR INHIBIN; MUCINOUS CYSTADENOCARCINOMA OF THE OVARY; MONITORING OF OVARIAN CANCER; BENIGN OVARIAN TUMORS; CA125; CEA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
I. Phocas et al., "A COMPARATIVE-STUDY OF SERUM ALPHA-BETA-A IMMUNOREACTIVE INHIBIN AND TUMOR-ASSOCIATED ANTIGENS CA125 AND CEA IN OVARIAN-CANCER", Anticancer research, 16(6B), 1996, pp. 3827-3831

Abstract

a-i.r Inhibin, has been recently proposed as a useful tumor marker for mucinous ovarian carcinomas (Ca), as the widely used tumor marker for ovarian malignancies, CA125 is efficient only in nonmucinous ovarianCa, and, together with CEA, fails to detect minimal disease and show long half-life in serum after successful surgery. Moreover, conflicting evidence has been reported as to whether inhibin in ovarian malignancies is the biologically active dimer alpha-beta A inhibin or the inactive free alpha-subunits and inhibin precursors. Serum alpha-beta A i.r inhibin, CA125 and CEA were measured preoperatively and 8 days postoperatively in 39 postmenopausal patients with ovarian cancer (13 mucinous, 15 serous and 11 different other ovarian Ca) in comparison with 20 age-matched healthy women (Controls), 18 patients with benign ovarian tumors and 10 patients with nonovarian gynecological malignancies. Serum alpha-beta A i.r inhibin values were very low in control (0.121 U/ml; 0.060-0.250) while they were greatly elevated in both benign (67%sensitivity) and malignant ovarian tumors (100% sensitivity in mucinous Ca, 80% in serous and 90.9% in other ovarian Ca, taken as cut-off level the maximum value in Controls, 0.250 U/ml). In contrast, in non-ovarian malignancies no increased values of alpha-beta A inhibin were found (0% sensitivity). Our results on the sensitivity of CA125 and CEAare in agreement with previous studies. After successful surgery the very high concentrations of alpha-beta A i.r inhibin were reduced veryrapidly (8 days) to normal postmenopausal values in contrast to thoseof CA125 and CEA, that remained elevated. Serum alpha-beta A ir inhibin seems to be very useful in monitoring after treatment the patients with any type ovarian malignancy and specifically those with mucinous ovarian cancer.

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Documento generato il 28/11/20 alle ore 03:14:03