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Titolo:
L-HISTIDINOL REVERSES RESISTANCE TO CISPLATINUM AND OTHER ANTINEOPLASTICS IN A TUMORIGENIC EPITHELIAL-CELL LINE
Autore:
WARRINGTON RC; FANG WD; ZHANG L;
Indirizzi:
UNIV SASKATCHEWAN,DEPT BIOCHEM,107 WIGGINS RD SASKATOON SK S7N 5E5 CANADA UNIV SASKATCHEWAN,SASKATOON CANC CTR SASKATOON SK S7N 5E5 CANADA
Titolo Testata:
Anticancer research
fascicolo: 6B, volume: 16, anno: 1996,
pagine: 3641 - 3646
SICI:
0250-7005(1996)16:6B<3641:LRRTCA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL CANCER-CHEMOTHERAPY; ANTICANCER DRUGS; HOMOHARRINGTONINE; 5-FLUOROURACIL; PHENOTYPE; EFFICACY; LEUKEMIA; PROTEIN;
Keywords:
KIDNEY EPITHELIAL CELLS; CISPLATINUM AND ANTIMETABOLITE RESISTANCE; L-HISTIDINOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
R.C. Warrington et al., "L-HISTIDINOL REVERSES RESISTANCE TO CISPLATINUM AND OTHER ANTINEOPLASTICS IN A TUMORIGENIC EPITHELIAL-CELL LINE", Anticancer research, 16(6B), 1996, pp. 3641-3646

Abstract

L-Histidinol protects normal cells from various anticancer drugs, while enhancing the toxicity of the same agents in drug-sensitive and multidrug-resistant tumor cells. Here, we report that L-histidinol circumvents a novel form of multiple-drug resistance in the MDCK-T1 line, a tumorigenic derivative of the phenotypically-normal Madin-Darby caninekidney (MDCK) epithelial cell line. Clonogenic cell survival assays showed that, compared to the parental MDCK line, the MDCK-T1 line was resistant to 1,3-bis(2-chloroethyl)-1-nitrosourea (similar to 15 fold),to cisplatinum (similar to 10 fold), to 5-fluorouracil (similar to 10-fold) and to cytosine arabinoside (similar to 15-fold). L-Histidinol reversed the resistance of MDCK line from these agents. These studies indicate that L-histidinol reverses a unique form of drug-resistance in MDCK-T1 cells by a mechanism dependent upon protein synthesis inhibition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 14:05:50