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Titolo:
L-HISTIDINOL SELECTIVELY MODULATES DAUNOMYCIN TOXICITY IN NORMAL AND TUMORIGENIC KIDNEY EPITHELIAL-CELLS
Autore:
WARRINGTON RC; FANG WD; ZHANG L; SHIEH M; SAIER MH;
Indirizzi:
UNIV SASKATCHEWAN,DEPT BIOCHEM,107 WIGGINS RD SASKATOON SK S7N 5E5 CANADA UNIV SASKATCHEWAN,SASKATOON CANC CTR SASKATOON SK S7N 5E5 CANADA UNIV CALIF SAN DIEGO,DEPT BIOL LA JOLLA CA 92093
Titolo Testata:
Anticancer research
fascicolo: 6B, volume: 16, anno: 1996,
pagine: 3629 - 3633
SICI:
0250-7005(1996)16:6B<3629:LSMDTI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL CANCER-CHEMOTHERAPY; ANTICANCER DRUGS; EFFICACY; MICE; B16F10-MELANOMA; 5-FLUOROURACIL; LEUKEMIA; DISEASE;
Keywords:
KIDNEY EPITHELIAL CELLS; DAUNOMYCIN; L-HISTIDINOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
R.C. Warrington et al., "L-HISTIDINOL SELECTIVELY MODULATES DAUNOMYCIN TOXICITY IN NORMAL AND TUMORIGENIC KIDNEY EPITHELIAL-CELLS", Anticancer research, 16(6B), 1996, pp. 3629-3633

Abstract

L-Histidinol protects normal cells from anticancer drugs while enhancing the ability of these agents to eradicate tumor cells. We now report that this attribute, previously documented in normal and turner cells of fibroblastic or myeloid origin, extends to epithelial lines. Clonogenic cell survival assays showed that L-histidinol protected the normal Madin-Darby canine kidney (MDCK) epithelial cell line from daunomycin (DAU) toxicity, brit enhanced DAU toxicity in IMDCK-T1, a tumorigenic derivative of MDCK. The protection of MDCK cells from DAU by L-histidinol was improved by increasing L-histidine in the media, a condition known to diminish L-histidinol's capacity to inhibit protein synthesis. In contrast, similar conditions markedly diminished the capacity of L-histidinol to enhance DAU killing of MDCK-T1 cells. These data suggest that the differential effects of L-histidinol an DAU toxicity cannot be attributed totally to its ability to inhibit protein synthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:09:51